Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10072037 | 0.89 | SCN9A (0.62) | SCN9AKMT2AMITFDRD4ALDH1A1 | |
| SCHEMBL1709219 | 0.88 | SCN9A (0.74) | SCN9AKMT2AMITFDRD4ALDH1A1 | |
| SCHEMBL1286845 | 0.86 | SCN9A (0.66) | SCN9AKMT2AMITFDRD4ALDH1A1 | |
| SCHEMBL10072166 | 0.83 | SCN9A (0.60) | SCN9AKMT2AMITFDRD4ALDH1A1 | |
| SCHEMBL1709220 | 0.83 | SCN9A (0.55) | SCN9AKMT2AMITFDRD4 | |
| SCHEMBL1709222 | 0.79 | SCN9A (0.60) | SCN9AKMT2ADRD4ALDH1A1POLB | |
| SCHEMBL10072036 | 0.79 | SCN9A (0.55) | SCN9AKMT2ADRD4ALDH1A1POLB | |
| SCHEMBL10072168 | 0.79 | SCN9A (0.56) | SCN9AKMT2ADRD4ALDH1A1POLB | |
| SCHEMBL1709207 | 0.77 | SCN9A (0.54) | SCN9AKMT2ADRD4ALDH1A1POLB | |
| SCHEMBL1709255 | 0.77 | SCN9A (0.57) | SCN9AKMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |