Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.59 |
| ▸ | USP2 | O75604 | 4/20 | 0.50 |
| ▸ | PTPRA | P18433 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15651304 | 0.86 | GFER (0.46) | HRH3USP2SYKALDH1A1CYP2C19 | |
| SCHEMBL1286810 | 0.80 | HRH3 (0.50) | HRH3USP2SCN9AALDH1A1CYP2C19 | |
| SCHEMBL1286789 | 0.78 | HPGD (0.53) | HRH3USP2ALDH1A1TSHRTP53 | |
| SCHEMBL1286796 | 0.75 | USP2 (0.49) | HRH3USP2PTPRASCN9AALDH1A1 | |
| SCHEMBL14812968 | 0.74 | CYP3A4 (0.57) | USP2ALDH1A1CYP2C19CYP3A4MAPK1 | |
| SCHEMBL21726748 | 0.74 | KMT2A (0.42) | HRH3ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL21726745 | 0.74 | KMT2A (0.42) | HRH3ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4433783 | 0.74 | USP2 (0.54) | USP2PTPRAALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL1709267 | 0.73 | USP2 (0.44) | HRH3USP2PTPRASCN9AALDH1A1 | |
| SCHEMBL9432297 | 0.72 | USP2 (0.56) | USP2PTPRAALDH1A1CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |