Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 4/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1709241 | 0.76 | SCN9A (0.54) | USP2CYP2D6SCN9ASIGMAR1HRH3 | |
| SCHEMBL1286820 | 0.75 | HRH3 (0.59) | USP2CYP2D6SCN9ALMNAHRH3 | |
| SCHEMBL1709267 | 0.75 | USP2 (0.44) | USP2CYP2D6SCN9ALMNAHTR3E | |
| SCHEMBL1709269 | 0.73 | USP2 (0.74) | USP2CYP2D6LMNAHTR3EHTR3B | |
| SCHEMBL5804237 | 0.72 | USP2 (0.52) | USP2CYP2D6LMNAHTR3EHTR3B | |
| SCHEMBL1107775 | 0.71 | USP2 (0.55) | USP2CYP2D6LMNAHTR3EHTR3B | |
| SCHEMBL931643 | 0.71 | MBTD1 (0.57) | CYP2D6LMNAHTR3EHTR3BADRB1 | |
| SCHEMBL13673998 | 0.71 | USP2 (0.55) | USP2CYP2D6LMNAHTR3EHTR3B | |
| SCHEMBL576454 | 0.71 | LMNA (0.67) | USP2CYP2D6LMNAHTR3EHTR3B | |
| SCHEMBL576814 | 0.71 | LMNA (0.67) | USP2CYP2D6LMNAHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |
| WO-2012047703-A2 | CYCLOPROPYL-SPIRO-PIPERIDINES USEFUL AS SODIUM CHANNEL BLOCKERS | SCHERING CORPORATION (US) | 2012-04-12 | — | — | WO | disclosed |