Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 13/20 | 0.57 |
| ▸ | TSHR | P16473 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 5/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30449070 | 0.92 | CYP3A4 (0.53) | CYP3A4TSHRALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL18838469 | 0.80 | SMN1; SMN2 (0.61) | ALDH1A1SMN1; SMN2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL18838292 | 0.80 | SMN1; SMN2 (0.61) | ALDH1A1SMN1; SMN2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL2798935 | 0.80 | SMN1; SMN2 (0.61) | ALDH1A1SMN1; SMN2CYP2C19CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL18838470 | 0.79 | SMN1; SMN2 (0.60) | ALDH1A1SMN1; SMN2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL1286789 | 0.78 | HPGD (0.53) | TSHRALDH1A1TP53USP2HPGD | |
| SCHEMBL11882343 | 0.78 | MGLL (0.72) | CYP3A4TSHRALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL26089744 | 0.77 | CYP3A4 (0.64) | CYP3A4TSHRALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL614078 | 0.77 | CYP3A4 (0.59) | CYP3A4TSHRALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL1578826 | 0.74 | ALDH1A1 (0.78) | CYP3A4TSHRALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3292110-B1 | N-PIPERIDIN-4-YL DERIVATIVES | MERCK SHARP & DOHME (NL) | 2019-08-21 | — | — | EP | disclosed |
| EP-3292110-A1 | N-PIPERIDIN-4-YL DERIVATIVES | Merck Sharp & Dohme B.V. (NL) | 2018-03-14 | — | — | EP | disclosed |
| US-8993757-B2 | N-piperidin-4-yl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2015-03-31 | — | — | US | disclosed |
| US-20140329822-A1 | N-PIPERIDIN-4-YL DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2014-11-06 | — | — | US | disclosed |
| WO-2013041457-A1 | N-PIPERIDIN-4-YL DERIVATIVES | MSD OSS B.V. (NL) | 2013-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329822-A1 | N-PIPERIDIN-4-YL DERIVATIVES | PGR, CYP19A1, BRCA1 | CYP3A4 1734/4885TSHR 1448/4885ALDH1A1 1486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.