Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC29A1 | Q99808 | 4/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | CTH | P32929 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1286899 | 0.93 | MAPT (0.37) | MAPTSMN1; SMN2SLC29A1CRHR1MEN1 | |
| SCHEMBL1286890 | 0.93 | MAPT (0.37) | MAPTSMN1; SMN2SLC29A1CRHR1MEN1 | |
| SCHEMBL1032549 | 0.87 | SLC29A1 (0.41) | MAPTSMN1; SMN2SLC29A1CRHR1MEN1 | |
| SCHEMBL8654321 | 0.83 | MAPT (0.42) | MAPTSMN1; SMN2SLC29A1CRHR1MEN1 | |
| SCHEMBL3809519 | 0.83 | CTH (0.35) | MAPTSMN1; SMN2SLC29A1LMNADHFR | |
| SCHEMBL2838653 | 0.82 | SLC29A1 (0.54) | MAPTSMN1; SMN2SLC29A1MEN1KMT2A | |
| SCHEMBL28561296 | 0.81 | DNM1 (0.37) | MAPTSMN1; SMN2SLC29A1LMNADHFR | |
| SCHEMBL1081509 | 0.81 | SLC29A1 (0.42) | MAPTSMN1; SMN2SLC29A1CRHR1MEN1 | |
| SCHEMBL5355585 | 0.80 | MAPT (0.50) | MAPTSMN1; SMN2SLC29A1CRHR1MEN1 | |
| SCHEMBL13250500 | 0.80 | CRHR1 (0.49) | MAPTSMN1; SMN2SLC29A1CRHR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047630-A2 | N-ALKYL OR N-ARYL SUBSTITUTED GUANIDE AND BIGUANIDE COMPOUNDS AND METHODS OF THEIR USE | TEINTZE MARTIN (US) | 2012-04-12 | — | — | WO | disclosed |