Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.45 |
| ▸ | KDM5C | P41229 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.45 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.44 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9736097 | 0.83 | KDM4C (0.54) | NPC1HPGDRAB9ASMN1; SMN2KDM4C | |
| SCHEMBL1287025 | 0.80 | KDM5C (0.51) | HPGDSMN1; SMN2KDM4CKDM5CKDM4E | |
| SCHEMBL31752670 | 0.77 | MAPK1 (0.54) | NPC1HPGDRAB9ASMN1; SMN2KDM4C | |
| SCHEMBL580585 | 0.77 | KDM5B (0.56) | NPC1HPGDRAB9ASMN1; SMN2KDM4C | |
| SCHEMBL1287029 | 0.76 | KDM4C (0.44) | NPC1HPGDRAB9ASMN1; SMN2KDM4C | |
| SCHEMBL17144910 | 0.75 | JMJD6 (0.42) | NPC1HPGDRAB9ASMN1; SMN2KDM4C | |
| SCHEMBL17835560 | 0.74 | KDM4E (0.54) | SMN1; SMN2KDM4ENAMPTLMNAMEN1 | |
| SCHEMBL10263738 | 0.74 | KDM4E (0.57) | NPC1HPGDRAB9ASMN1; SMN2KDM4C | |
| SCHEMBL31320065 | 0.74 | KDM4E (0.57) | NPC1HPGDRAB9ASMN1; SMN2KDM4C | |
| SCHEMBL30740808 | 0.74 | KDM4C (0.57) | NPC1HPGDRAB9ASMN1; SMN2KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012047156-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS PLASMINOGEN INHIBITORS AND THEIR USE IN THE TREATMENT OF FIBRINOLYSIS RELATED DISEASES | ASTRAZENECA AB (SE) | 2012-04-12 | — | — | WO | disclosed |