Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.54 |
| ▸ | KDM5C | P41229 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | KDM6B | O15054 | 1/20 | 0.51 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.51 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.51 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.49 |
| ▸ | WNT1 | P04628 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CHKA | P35790 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1287025 | 0.88 | KDM5C (0.51) | KDM4CKDM5CKDM4EKDM6BKDM2A | |
| SCHEMBL17144910 | 0.85 | JMJD6 (0.42) | KDM4CKDM5CKDM4EKDM6BKDM2A | |
| SCHEMBL1287113 | 0.83 | NPC1 (0.45) | KDM4CKDM5CKDM4EKDM6BKDM2A | |
| SCHEMBL2305288 | 0.82 | KDM4C (0.76) | KDM4CKDM5CKDM4EKDM6BKDM2A | |
| SCHEMBL1287029 | 0.81 | KDM4C (0.44) | KDM4CKDM5CKDM4EKDM6BKDM2A | |
| SCHEMBL16291774 | 0.81 | KDM4C (0.74) | KDM4CKDM5CKDM4EKDM6BKDM2A | |
| SCHEMBL6017370 | 0.81 | ALDH1A1 (0.47) | KDM4CKDM5CKDM4EKDM6BKDM2A | |
| SCHEMBL15636986 | 0.80 | SMYD2 (0.46) | KDM4CKDM5CKDM4EKDM6BKDM2A | |
| SCHEMBL15636461 | 0.80 | KDM4C (0.76) | KDM4CKDM5CKDM4EKDM6BKDM2A | |
| SCHEMBL1286996 | 0.79 | KDM4C (0.44) | KDM4CKDM5CKDM4EKDM6BKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5114945-A | Spiropiperidine derivatives | GLAXO GROUP LIMITED (GB) | 1992-05-19 | — | — | US | disclosed |
| EP-0330461-A2 | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 1989-08-30 | — | — | EP | disclosed |