SCHEMBL1287433

SCHEMBL1287433

[CH2]c1cccc(Cc2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.57
IDH1 O75874 1/20 0.48
PRSS1 P07477 1/20 0.47
PRSS2 P07478 1/20 0.47
PRSS3 P35030 1/20 0.47
BCL2 P10415 1/20 0.41
BCL2L1 Q07817 1/20 0.41
HNF4A P41235 1/20 0.41
LOXL2 Q9Y4K0 1/20 0.40
LTA4H P09960 1/20 0.40
ACMSD Q8TDX5 1/20 0.40
MTNR1A P48039 1/20 0.39
MTNR1B P49286 1/20 0.39
PLA2G10 O15496 1/20 0.38
PLA2G2A P14555 1/20 0.38
LMNA P02545 1/20 0.38
MPO P05164 1/20 0.37
SLC5A2 P31639 1/20 0.37
PTPN5 P54829 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10546085 0.83 SLC5A2 (0.42) CALM1IDH1PRSS1PRSS2PRSS3
SCHEMBL28144763 0.83 IDH1 (0.38) CALM1IDH1PRSS1PRSS2PRSS3
SCHEMBL10545328 0.83 PTPN5 (0.41) CALM1IDH1LTA4HLMNAPTPN5
SCHEMBL10544415 0.83 PTPN5 (0.42) CALM1IDH1LOXL2LMNAPTPN5
SCHEMBL7613502 0.82 CALM1 (0.75) CALM1IDH1PRSS1PRSS2PRSS3
SCHEMBL13971231 0.82 CALM1 (0.75) CALM1IDH1PRSS1PRSS2PRSS3
SCHEMBL393865 0.81 MAOA (0.56) LOXL2
SCHEMBL1718228 0.77 CALM1 (0.67) CALM1IDH1BCL2BCL2L1HNF4A
SCHEMBL5538533 0.76 CALM1 (0.57) CALM1IDH1PRSS1PRSS2PRSS3
Diphenylmethane SCHEMBL11290187 0.76 CALM1 (0.86) CALM1IDH1BCL2BCL2L1LOXL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0171249-A2 Improvements relating to pesticides NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1986-02-12 EP claimed
CN-111491963-B Method for producing (meth) acrylic composition, coating material containing (meth) acrylic composition, and cured body 三菱瓦斯化学株式会社 2023-04-28 CN disclosed
CN-113710750-B (meth) acrylic composition, coating material containing same, and cured product 三菱瓦斯化学株式会社 2022-07-12 CN disclosed
US-20220145118-A1 (METH)ACRYLIC COMPOSITION, PAINT AND CURING AGENT COMPRISING SAME MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2022-05-12 US disclosed
US-11326073-B1 (meth)acrylic composition, paint and curing agent comprising same MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2022-05-10 US disclosed
CN-113710750-A (meth) acrylic composition, coating material containing same, and cured product 三菱瓦斯化学株式会社 2021-11-26 CN disclosed
WO-2021195723-A1 \"METHODS FOR TREATMENT OF CORONAVIRUS INFECTIONS\ THE COUNCIL OF THE QUEENSLAND INSTITUTE OF MEDICAL RESEARCH (AU) 2021-10-07 WO disclosed
CN-108603953-B Light diffusing agent, light diffusing resin composition, and molded article 三菱瓦斯化学株式会社 2021-08-24 CN disclosed
US-20210186905-A1 ENHANCING T-CELL FUNCTION AND TREATING A T-CELL DYSFUNCTIONAL DISORDER WITH A COMBINATION OF AN LSD INHIBITOR AND A PD-1 BINDING ANTAGONIST EPIAXIS THERAPEUTICS PTY LTD (AU) 2021-06-24 US disclosed
US-20210121496-A1 METHODS AND COMPOSITIONS FOR MODULATING CANCER STEM CELLS EpiAxis Therapeutics Pty Ltd. (AU) 2021-04-29 US disclosed
US-4570005-A REACTING THE ARYL PROPYL CHLORIDE WITH THE CORRESPONDING ARYL ALCOHOL OR ARYL MERCAPTAN MITSUITOATSU CHEMICALS INC. (JP) 1986-02-11 US disclosed
EP-0161921-A2 Improvements relating to pesticides BTG INTERNATIONAL LIMITED (GB) 1985-11-21 EP disclosed
US-4532258-A Controlling insects, mites, pests KURARAY CO., LTD. (JP) 1985-07-30 US disclosed
US-4464391-A Pesticides NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1984-08-07 US disclosed
US-4411912-A Insecticidal isovaleric acid esters ZOECON CORPORATION (US) 1983-10-25 US disclosed
US-4397864-A LOW TOXICITY MITSUITOATSU CHEMICALS INC. (JP) 1983-08-09 US disclosed
US-4390547-A 2,2-Dimethyl-3-(substituted ethyl)cyclopropane carboxylate pesticidal compositions and methods KURARAY CO., LTD. (JP) 1983-06-28 US disclosed
US-4299839-A Novel pesticides and pesticidal compositions cyclopropanecarboxylates and pesticidal method KURARAY CO., LTD. (JP) 1981-11-10 US disclosed
US-4243819-A Substituted amino acids ZOECON CORPORATION (US) 1981-01-06 US disclosed
EP-0006155-A1 3-Phenoxybenzyl amines and 3-benzylbenzyl amines and process for their production CIBA-GEIGY AG (CH) 1980-01-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210186905-A1 ENHANCING T-CELL FUNCTION AND TREATING A T-CELL DYSFUNCTIONAL DISORDER WITH A COMBINATION OF AN LSD INHIBITOR AND A PD-1 BINDING ANTAGONIST PDCD1, CD274, PDCD1LG2 CALM1 578/4885IDH1 3813/4885PRSS1 1058/4885
US-20210121496-A1 METHODS AND COMPOSITIONS FOR MODULATING CANCER STEM CELLS BMI1, KDM1B, KDM6B CALM1 1057/4885IDH1 584/4885PRSS1 3786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.