Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 6/20 | 0.55 |
| ▸ | DHODH | Q02127 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1163234 | 0.80 | ALDH1A1 (0.52) | SCN9ADHODHALDH1A1MAPTKMT2A | |
| SCHEMBL8794131 | 0.78 | DHODH (0.76) | SCN9ADHODHLMNA | |
| SCHEMBL16168182 | 0.76 | SCN9A (0.54) | SCN9ADHODHALDH1A1LMNAMAPT | |
| SCHEMBL8795029 | 0.76 | SCN9A (0.57) | SCN9ADHODHALDH1A1LMNAMAPT | |
| SCHEMBL1162693 | 0.72 | BTK (0.56) | SCN9ADHODH | |
| SCHEMBL28029893 | 0.72 | KDM4E (0.61) | SCN9ADHODHALDH1A1LMNAMAPT | |
| SCHEMBL31061268 | 0.72 | CYP1A1 (0.73) | SCN9AMAPTKMT2AMEN1KDM1A | |
| SCHEMBL19203180 | 0.72 | BTK (0.45) | SCN9AALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL12874595 | 0.71 | MAOA (0.61) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL13912112 | 0.71 | KMT2A (0.53) | DHODHALDH1A1LMNAKMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011019780-A1 | AZAINDAZOLES AS BTK KINASE MODULATORS AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-17 | — | — | WO | disclosed |