Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 7/20 | 0.54 |
| ▸ | DHODH | Q02127 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800658 | 0.79 | DHODH (0.41) | SCN9ADHODHNPC1RAB9A | |
| SCHEMBL8794131 | 0.78 | DHODH (0.76) | SCN9ADHODHLMNA | |
| SCHEMBL18800638 | 0.77 | DHPS (0.41) | SCN9AALDH1A1ADORA2ANPC1RAB9A | |
| SCHEMBL18800779 | 0.76 | XDH (0.47) | SCN9ANPC1RAB9A | |
| SCHEMBL12874592 | 0.76 | SCN9A (0.55) | SCN9ADHODHALDH1A1ADORA2AMEN1 | |
| SCHEMBL18800677 | 0.75 | MCL1 (0.46) | SCN9AALDH1A1MEN1LMNAMAPT | |
| SCHEMBL18800780 | 0.75 | SCN9A (0.44) | SCN9ADHODHALDH1A1MEN1LMNA | |
| SCHEMBL18800795 | 0.75 | BTK (0.43) | SCN9A | |
| SCHEMBL18800635 | 0.75 | BTK (0.48) | SCN9AADORA2A | |
| SCHEMBL18800412 | 0.75 | BTK (0.43) | SCN9AADORA2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-A1 | Azaindazoles as Btk kinase modulators and use thereof | Bristol-Myers Squibb Company (US) | 2014-10-15 | — | — | EP | disclosed |