Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 3/20 | 0.34 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | USP7 | Q93009 | 2/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | BAX | Q07812 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800739 | 0.82 | MEN1 (0.39) | KMT2AESR2MEN1ESR1RPS6KA3 | |
| SCHEMBL18800606 | 0.73 | NQO2 (0.43) | KMT2ARPS6KA3LTA4HST14F2 | |
| SCHEMBL12874718 | 0.71 | BTK (0.43) | KMT2AMEN1LTA4HPLAUBTK | |
| SCHEMBL18800557 | 0.68 | PRSS1 (0.45) | KMT2ARPS6KA3HTT | |
| SCHEMBL18800626 | 0.68 | SMN1; SMN2 (0.48) | KMT2AMEN1F2BTKNPSR1 | |
| SCHEMBL30047702 | 0.64 | DGAT1 (0.53) | KMT2AESR2MEN1ESR1RPS6KA3 | |
| SCHEMBL18780266 | 0.64 | BTK (0.53) | KMT2AMEN1LTA4HBTKNR1H2 | |
| SCHEMBL2905032 | 0.63 | ESR2 (0.56) | KMT2AESR2MEN1ESR1LTA4H | |
| SCHEMBL19286912 | 0.63 | ST14 (0.83) | KMT2AESR2MEN1ESR1ST14 | |
| SCHEMBL18800873 | 0.62 | SCN5A (0.37) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011019780-A1 | AZAINDAZOLES AS BTK KINASE MODULATORS AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-02-17 | — | — | WO | disclosed |