Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NQO2 | P16083 | 2/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800606 | 0.96 | NQO2 (0.43) | PRSS1PRSS2PRSS3MAPTMAP4K4 | |
| SCHEMBL18800626 | 0.86 | SMN1; SMN2 (0.48) | PRSS1PRSS2PRSS3MAPTCYP1A2 | |
| SCHEMBL18800867 | 0.85 | BTK (0.50) | PRSS1PRSS2PRSS3MAPTMAP4K4 | |
| SCHEMBL18800738 | 0.83 | TDO2 (0.49) | PRSS1PRSS2PRSS3MAPTCYP1A2 | |
| SCHEMBL18800739 | 0.83 | MEN1 (0.39) | PRSS1PRSS2PRSS3KMT2ARPS6KA3 | |
| SCHEMBL18800873 | 0.82 | SCN5A (0.37) | CYP11B1CYP11B2 | |
| SCHEMBL18800479 | 0.79 | BTK (0.54) | MAP4K4TSHR | |
| SCHEMBL18800610 | 0.76 | BTK (0.43) | PRSS1PRSS2PRSS3MAPTMAP4K4 | |
| SCHEMBL18800598 | 0.75 | KDM4E (0.51) | PRSS1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18800716 | 0.72 | PRKCQ (0.37) | PRSS1MAPTCYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |