SCHEMBL1287486

SCHEMBL1287486

O=S(=O)(NCCCc1ccccc1)c1cccc(Cl)c1Cl

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 5/20 0.68
CYP3A4 P08684 5/20 0.68
CYP2C19 P33261 5/20 0.68
ALDH1A1 P00352 4/20 0.68
TDP1 Q9NUW8 4/20 0.68
CYP2C9 P11712 4/20 0.68
MAPK1 P28482 4/20 0.68
KDM4E B2RXH2 1/20 0.68
TP53 P04637 5/20 0.59
GAA P10253 1/20 0.59
POLB P06746 1/20 0.53
TPSAB1 Q15661 1/20 0.50
CYP2D6 P10635 3/20 0.49
NSD2 O96028 2/20 0.49
THPO P40225 2/20 0.49
NFKB1 P19838 1/20 0.49
TSHR P16473 3/20 0.48
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
GMNN O75496 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2875881 0.86 ALDH1A1 (0.58) CYP1A2CYP3A4CYP2C19ALDH1A1TDP1
SCHEMBL29508099 0.81 CYP3A4 (1.00) CYP1A2CYP3A4CYP2C19ALDH1A1TDP1
SCHEMBL317956 0.81 CYP3A4 (1.00) CYP1A2CYP3A4CYP2C19ALDH1A1TDP1
SCHEMBL9577190 0.79 CYP3A4 (0.72) CYP1A2CYP3A4CYP2C19ALDH1A1TDP1
SCHEMBL9659233 0.79 ALDH1A1 (0.64) CYP1A2CYP3A4CYP2C19ALDH1A1TDP1
SCHEMBL9577205 0.78 CYP3A4 (0.75) CYP1A2CYP3A4CYP2C19ALDH1A1TDP1
SCHEMBL411204 0.78 TDP1 (0.74) CYP1A2CYP3A4CYP2C19ALDH1A1TDP1
SCHEMBL1287452 0.77 ALDH1A1 (0.59) CYP1A2CYP3A4CYP2C19ALDH1A1TDP1
SCHEMBL2880609 0.77 ALDH1A1 (0.56) CYP1A2CYP3A4CYP2C19ALDH1A1TDP1
SCHEMBL12916500 0.77 FABP4 (0.51) CYP1A2CYP3A4CYP2C19ALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012047926-A2 SULFONAMIDE-CONTAINING COMPOUNDS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2012-04-12 WO disclosed