Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH1 | Q13686 | 8/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GLP1R | P43220 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12876134 | 0.92 | GRM2 (0.41) | ALKBH1KLKB1MAOBL3MBTL1NPC1 | |
| SCHEMBL1197965 | 0.89 | ALKBH1 (0.49) | ALKBH1KLKB1MAOBKDM5AKDM4C | |
| SCHEMBL2861439 | 0.89 | ALKBH1 (0.51) | ALKBH1MAOBKDM5AKDM4CKDM5B | |
| SCHEMBL1199018 | 0.83 | ALDH1A1 (0.41) | ALKBH1KLKB1MAOBPTGER1L3MBTL1 | |
| SCHEMBL12876017 | 0.82 | MEN1 (0.41) | ALKBH1KLKB1L3MBTL1NPC1RAB9A | |
| SCHEMBL12875802 | 0.82 | L3MBTL1 (0.39) | ALKBH1KLKB1L3MBTL1NPC1CASP3 | |
| SCHEMBL12876129 | 0.82 | KMT2A (0.45) | ALKBH1KLKB1KDM4CPPARAPPARD | |
| SCHEMBL2864450 | 0.80 | ALKBH1 (0.50) | ALKBH1KDM5AKDM5BPPARAPPARD | |
| SCHEMBL12875995 | 0.80 | ALKBH1 (0.48) | ALKBH1KLKB1L3MBTL1PPARAPPARD | |
| SCHEMBL2868652 | 0.78 | ALKBH1 (0.45) | ALKBH1KDM5AKDM4CKDM5BL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461348-B2 | Heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-11 | — | — | US | disclosed |
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | PDE3B, PDE5A, PDE2A | ALKBH1 1916/4885KLKB1 3765/4885MAOB 1137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.