Sugi Predict

Sugi Predict / Compounds / SCHEMBL1287632

SCHEMBL1287632

SCHEMBL1287632

CCc1oc2ccccc2c1C(=O)c1ccc(O)c(F)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EYA3 Q99504 7/20 0.68
▸ SLC22A12 Q96S37 4/20 0.68
▸ CYP2C9 P11712 7/20 0.64
▸ CYP2C19 P33261 6/20 0.64
▸ MEN1 O00255 2/20 0.64
▸ ABCB11 O95342 2/20 0.64
▸ LMNA P02545 2/20 0.64
▸ TTR P02766 2/20 0.64
▸ PGR P06401 2/20 0.64
▸ ADRA2A P08913 2/20 0.64
▸ TBXA2R P21731 2/20 0.64
▸ OPRM1 P35372 2/20 0.64
▸ SLC6A3 Q01959 2/20 0.64
▸ KMT2A Q03164 2/20 0.64
▸ BIRC5 O15392 1/20 0.64
▸ HTR1A P08908 1/20 0.64
▸ DRD1 P21728 1/20 0.64
▸ PTGS1 P23219 1/20 0.64
▸ SLC6A2 P23975 1/20 0.64
▸ PDE4A P27815 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9444916 0.86 CYP2C19 (0.77) EYA3SLC22A12CYP2C9CYP2C19MEN1
SCHEMBL1287955 0.85 EYA3 (0.68) EYA3SLC22A12CYP2C9CYP2C19MEN1
SCHEMBL1287675 0.85 EYA3 (0.79) EYA3SLC22A12CYP2C9CYP2C19MEN1
SCHEMBL1287583 0.85 CYP2C19 (0.77) EYA3SLC22A12CYP2C9CYP2C19MEN1
SCHEMBL1287594 0.84 CYP2C19 (0.63) EYA3SLC22A12CYP2C9CYP2C19MEN1
SCHEMBL1287385 0.83 EYA3 (0.77) EYA3SLC22A12CYP2C9CYP2C19MEN1
Cyanide SCHEMBL28104486 0.82 EYA3 (0.74) EYA3SLC22A12CYP2C9CYP2C19MEN1
SCHEMBL28104498 0.82 EYA3 (0.64) EYA3SLC22A12CYP2C9CYP2C19MEN1
Hydrochloric Acid SCHEMBL10615321 0.82 EYA3 (0.64) EYA3SLC22A12CYP2C9CYP2C19MEN1
Benzarone SCHEMBL555497 0.81 EYA3 (1.00) EYA3SLC22A12CYP2C9CYP2C19MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10005750-B2 Developing potent urate transporter inhibitors: compounds designed for their uricosuric action J-PHARMA CO., LTD. (JP) 2018-06-26 — — US disclosed
US-20130225673-A1 DEVELOPING POTENT URATE TRANSPORTER INHIBITORS: COMPOUNDS DESIGNED FOR THEIR URICOSURIC ACTION J-PHARMA CO., LTD. (JP) 2013-08-29 — — US disclosed
WO-2012048058-A2 DEVELOPING POTENT URATE TRANSPORTER INHIBITORS: COMPOUNDS DESIGNED FOR THEIR URICOSURIC ACTION J-PHARMA CO., LTD. (JP) 2012-04-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10005750-B2 Developing potent urate transporter inhibitors: compounds designed for their uricosuric action SLCO2B1, SLCO2A1, SLC10A6 EYA3 4828/4885SLC22A12 19/4885CYP2C9 203/4885
US-20130225673-A1 DEVELOPING POTENT URATE TRANSPORTER INHIBITORS: COMPOUNDS DESIGNED FOR THEIR URICOSURIC ACTION SLCO2B1, SLCO2A1, SLC10A6 EYA3 4828/4885SLC22A12 19/4885CYP2C9 203/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.