Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 3/20 | 0.53 |
| ▸ | RARB | P10826 | 3/20 | 0.53 |
| ▸ | RARG | P13631 | 3/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12876808 | 0.87 | MAPK14 (0.48) | RARARARBRARGPTGDR2MAPK14 | |
| SCHEMBL1198837 | 0.85 | ALDH1A1 (0.55) | RARARARBRARGMAPK14MEN1 | |
| SCHEMBL12876907 | 0.80 | RARB (0.54) | RARARARBRARGMAPK14MAPT | |
| SCHEMBL12876983 | 0.80 | HDAC6 (0.59) | RARARARBRARGPTGDR2MEN1 | |
| SCHEMBL12877014 | 0.79 | SYK (0.56) | RARBRARGPTGDR2MAPK14MAPT | |
| SCHEMBL12876767 | 0.79 | SIRT5 (0.50) | MAPK14CSNK1DCSNK1EMEN1KMT2A | |
| SCHEMBL27978170 | 0.76 | MEN1 (0.52) | RARARARBRARGPTGDR2MEN1 | |
| SCHEMBL12876898 | 0.74 | TP53 (0.57) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL12876953 | 0.72 | RAB9A (0.77) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL12876889 | 0.72 | PPARG (0.44) | RARARARBRARGMAPK14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461348-B2 | Heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-06-11 | — | — | US | disclosed |
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110028493-A1 | HETEROCYCLIC DERIVATIVE AND USE THEREOF | PDE3B, PDE5A, PDE2A | RARA 2748/4885RARB 2205/4885RARG 2182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.