Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | MAPT | P10636 | 2/20 | 0.80 |
| ▸ | RGS12 | O14924 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.80 |
| ▸ | PKM | P14618 | 1/20 | 0.80 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.80 |
| ▸ | THPO | P40225 | 1/20 | 0.80 |
| ▸ | MTOR | P42345 | 1/20 | 0.80 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.80 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | GMNN | O75496 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | G6PD | P11413 | 1/20 | 0.78 |
| ▸ | HPGD | P15428 | 1/20 | 0.78 |
| ▸ | RECQL | P46063 | 1/20 | 0.78 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12877903 | 0.90 | DRD2 (0.72) | DRD2ALDH1A1MAPTRGS12CYP1A2 | |
| SCHEMBL29602749 | 0.89 | DRD2 (1.00) | DRD2ALDH1A1MAPTRGS12CYP1A2 | |
| SCHEMBL107293 | 0.89 | DRD2 (1.00) | DRD2ALDH1A1MAPTRGS12CYP1A2 | |
| SCHEMBL140170 | 0.89 | DRD2 (1.00) | DRD2ALDH1A1MAPTRGS12CYP1A2 | |
| SCHEMBL8344207 | 0.89 | DRD2 (1.00) | DRD2ALDH1A1MAPTRGS12CYP1A2 | |
| Bromide SCHEMBL4923286 | 0.88 | MAPT (1.00) | DRD2ALDH1A1MAPTRGS12CYP1A2 | |
| Bromide SCHEMBL4923294 | 0.88 | MAPT (1.00) | DRD2ALDH1A1MAPTRGS12CYP1A2 | |
| Bromide SCHEMBL31027963 | 0.88 | MAPT (1.00) | DRD2ALDH1A1MAPTRGS12CYP1A2 | |
| SCHEMBL12878037 | 0.86 | DRD1 (1.00) | DRD2ALDH1A1MAPTRGS12CYP1A2 | |
| SCHEMBL12877888 | 0.85 | DRD2 (0.75) | DRD2ALDH1A1MAPTRGS12CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431591-B2 | R(−)-2-methoxy-11-hydroxyaporphine and derivatives thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2013-04-30 | — | — | US | disclosed |
| US-8431591-B2 | R(−)-2-methoxy-11-hydroxyaporphine and derivatives thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2013-04-30 | — | — | US | disclosed |
| US-20110034446-A1 | R(-)-2-METHOXY-11-HYDROXYAPORPHINE AND DERIVATIVES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
| US-20110034446-A1 | R(-)-2-METHOXY-11-HYDROXYAPORPHINE AND DERIVATIVES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110034446-A1 | R(-)-2-METHOXY-11-HYDROXYAPORPHINE AND DERIVATIVES THEREOF | SNCA, HTR3A, PARK7 | DRD2 18/4885ALDH1A1 972/4885MAPT 803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.