Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.36 |
| ▸ | FABP2 | P12104 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11994391 | 0.88 | LMNA (0.43) | LMNAAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL11994405 | 0.84 | AKR1C3 (0.42) | LMNAAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL30842572 | 0.77 | AKR1C3 (0.47) | LMNAAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL12892354 | 0.77 | HDAC1 (0.39) | MEN1KMT2AHPGDHDAC1HDAC8 | |
| SCHEMBL12570872 | 0.76 | LMNA (0.47) | LMNAAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL6902051 | 0.76 | LMNA (0.37) | LMNAAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL11994382 | 0.74 | NPC1 (0.46) | LMNAMEN1KMT2AMAPTHPGD | |
| SCHEMBL27631730 | 0.73 | ESR1 (0.48) | HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL26265862 | 0.73 | PTGS2 (0.47) | LMNAAKR1C3AKR1C2PTGS2PTGS1 | |
| SCHEMBL30957360 | 0.73 | ESR1 (0.48) | HDAC1HDAC8HDAC6HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110038876-A1 | HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS | SCHERING CORPORATION | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110038876-A1 | HETEROCYCLIC COMPOUNDS AND USE THEREOF AS ERK INHIBITORS | MAPK1, MAPK4, MAPK10 | LMNA 4001/4885AKR1C3 1236/4885AKR1C2 1030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.