Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.96 |
| ▸ | TOP2A | P11388 | 3/20 | 0.96 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | MAPT | P10636 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | BLM | P54132 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.74 |
| ▸ | GLA | P06280 | 1/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.74 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.74 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12888580 | 0.98 | TOP1 (1.00) | TOP1TOP2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16586786 | 0.89 | TOP1 (0.83) | TOP1TOP2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL12888575 | 0.88 | TOP1 (0.75) | TOP1TOP2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16586611 | 0.87 | TOP1 (0.80) | TOP1TOP2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL17968532 | 0.86 | TOP1 (0.78) | TOP1TOP2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL38686 | 0.85 | ALDH1A1 (1.00) | TOP1TOP2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL29350649 | 0.85 | ALDH1A1 (1.00) | TOP1TOP2AALDH1A1SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL29387917 | 0.84 | ALDH1A1 (0.98) | TOP1TOP2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4050825 | 0.84 | ALDH1A1 (0.76) | TOP1TOP2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL19975798 | 0.84 | TOP1 (0.76) | TOP1TOP2AALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9492554-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |
| US-9492554-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY (US) | 2016-11-15 | — | — | US | disclosed |
| US-20160263231-A1 | Methods and Compositions Related to Viral Inhibition | CLEMSON UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-20160263231-A1 | Methods and Compositions Related to Viral Inhibition | CLEMSON UNIVERSITY | 2016-09-15 | — | — | US | disclosed |
| US-9072761-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2015-07-07 | — | — | US | disclosed |
| US-9072761-B2 | Methods and compositions related to viral inhibition | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2015-07-07 | — | — | US | disclosed |
| US-20110046982-A1 | METHODS AND COMPOSITIONS RELATED TO VIRAL INHIBITION | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2011-02-24 | — | — | US | disclosed |
| US-20110046982-A1 | METHODS AND COMPOSITIONS RELATED TO VIRAL INHIBITION | CLEMSON UNIVERSITY RESEARCH FOUNDATION (CURF) (US) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160263231-A1 | Methods and Compositions Related to Viral Inhibition | EIF2AK2, NSUN2, NSUN3 | TOP1 612/4885TOP2A 716/4885ALDH1A1 4399/4885 |
| US-20110046982-A1 | METHODS AND COMPOSITIONS RELATED TO VIRAL INHIBITION | EIF2AK2, NSUN2, NSUN3 | TOP1 612/4885TOP2A 716/4885ALDH1A1 4399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.