Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.76 |
| ▸ | TOP2A | P11388 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | BLM | P54132 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.69 |
| ▸ | GLA | P06280 | 1/20 | 0.69 |
| ▸ | RECQL | P46063 | 1/20 | 0.69 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.69 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | TERT | O14746 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16586611 | 0.94 | TOP1 (0.80) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL17968532 | 0.93 | TOP1 (0.78) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL16586786 | 0.92 | TOP1 (0.83) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12888580 | 0.86 | TOP1 (1.00) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14453641 | 0.86 | ALDH1A1 (0.85) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14438587 | 0.85 | ALDH1A1 (0.79) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL23424055 | 0.85 | ALDH1A1 (0.78) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12888540 | 0.84 | TOP1 (0.96) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL23424044 | 0.84 | ALDH1A1 (0.80) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL23412226 | 0.82 | ALDH1A1 (0.74) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920014-B2 | Selective inhibition of bacterial topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-03-20 | — | — | US | disclosed |