Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.83 |
| ▸ | TOP2A | P11388 | 3/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.70 |
| ▸ | GLA | P06280 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.70 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19975798 | 0.92 | TOP1 (0.76) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL16586611 | 0.91 | TOP1 (0.80) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12888580 | 0.91 | TOP1 (1.00) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL17968532 | 0.90 | TOP1 (0.78) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12888540 | 0.89 | TOP1 (0.96) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14453641 | 0.87 | ALDH1A1 (0.85) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL23424055 | 0.85 | ALDH1A1 (0.78) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL23424044 | 0.84 | ALDH1A1 (0.80) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL14438587 | 0.84 | ALDH1A1 (0.79) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL23412226 | 0.83 | ALDH1A1 (0.74) | TOP1TOP2AALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9920014-B2 | Selective inhibition of bacterial topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-03-20 | — | — | US | claimed |
| US-20160229810-A1 | Selective Inhibition of Bacterial Topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2016-08-11 | — | — | US | claimed |
| US-9920014-B2 | Selective inhibition of bacterial topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-03-20 | — | — | US | disclosed |
| US-9920014-B2 | Selective inhibition of bacterial topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-03-20 | — | — | US | disclosed |
| US-9920014-B2 | Selective inhibition of bacterial topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2018-03-20 | — | — | US | disclosed |
| US-20160229810-A1 | Selective Inhibition of Bacterial Topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2016-08-11 | — | — | US | disclosed |
| US-20160229810-A1 | Selective Inhibition of Bacterial Topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2016-08-11 | — | — | US | disclosed |
| US-20160229810-A1 | Selective Inhibition of Bacterial Topoisomerase I | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2016-08-11 | — | — | US | disclosed |
| WO-2015042438-A1 | SELECTIVE INHIBITION OF BACTERIAL TOPOISOMERASE I | THE FLORIDA INTERNATIONAL BOARD OF TRUSTEES MODESTO A. MAIDIQUE CAMPUS (US) | 2015-03-26 | — | — | WO | disclosed |
| WO-2015042438-A1 | SELECTIVE INHIBITION OF BACTERIAL TOPOISOMERASE I | THE FLORIDA INTERNATIONAL BOARD OF TRUSTEES MODESTO A. MAIDIQUE CAMPUS (US) | 2015-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160229810-A1 | Selective Inhibition of Bacterial Topoisomerase I | TOP1, TOP2B, TOP2A | TOP1 1/4885TOP2A 3/4885ALDH1A1 3784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.