Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 14/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.75 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.75 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.75 |
| ▸ | HTR2C | P28335 | 1/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9994530 | 1.00 | SLC6A2 (0.75) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL12067194 | 1.00 | SLC6A2 (0.75) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL10358548 | 0.88 | SLC6A2 (0.79) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL16501556 | 0.88 | SLC6A2 (0.79) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL14325977 | 0.88 | SLC6A2 (0.79) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL15433960 | 0.87 | SLC6A2 (0.77) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL12067203 | 0.87 | SLC6A2 (0.77) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL9993370 | 0.87 | SLC6A2 (0.77) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| SCHEMBL1289614 | 0.87 | SLC6A2 (0.77) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C | |
| 1R,2S-Milnacipran SCHEMBL8099 | 0.86 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3CYP2D6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012046247-A2 | PROCESS FOR THE PREPARATION OF (±M1R(S), 2SRR)L-2-(AMINOMETHYL)-N,N-DIETHYL-L-PHENYLCYCLOPROPANE CARBOXAMIDE HYDROCHLORIDE | MSN LABORATORIES LIMITED (IN) | 2012-04-12 | — | — | WO | claimed |
| WO-2011158249-A1 | PROCESS FOR PREPARATION OF MILNACIPRAN INTERMEDIATE AND ITS USE IN PREPARATION OF PURE MILNACIPRAN | GLENMARK GENERICS LIMITED (IN) | 2011-12-22 | — | — | WO | claimed |
| EP-0377381-B1 | PROCESS FOR THE PREPARATION OF 1-PHENYL-1-DIETHYL AMINO-CARBONYL-2-PHTHALIMIDE METHYL CYCLOPROPANE Z | PIERRE FABRE MEDICAMENT (FR) | 1992-04-22 | — | — | EP | claimed |
| US-5034541-A | Method of preparing 1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethyl-cyclopropane-z | PIERRE FABRE MEDICAMENT (FR) | 1991-07-23 | — | — | US | claimed |
| CN-113493395-A | Preparation method of milnacipran hydrochloride intermediate | 北京万全德众医药生物技术有限公司 | 2021-10-12 | — | — | CN | disclosed |
| CN-111693614-A | Separation and determination method of related substances of levomilnacipran final product | 万全万特制药（厦门）有限公司 | 2020-09-22 | — | — | CN | disclosed |
| WO-2019097539-A1 | IMPROVED PROCESS FOR THE PREPARATION OF LEVOMILNACIPRAN | METROCHEM API PVT LTD. (IN) | 2019-05-23 | — | — | WO | disclosed |
| WO-2014009767-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF 1-ARYL 2-AMINOMETHYL CYCLOPROPANE CARBOXYAMIDE (Z) DERIVATIVES, THEIR ISOMERS AND SALTS | MICRO LABS LIMITED (IN) | 2014-01-16 | — | — | WO | disclosed |
| WO-2012046247-A2 | PROCESS FOR THE PREPARATION OF (±M1R(S), 2SRR)L-2-(AMINOMETHYL)-N,N-DIETHYL-L-PHENYLCYCLOPROPANE CARBOXAMIDE HYDROCHLORIDE | MSN LABORATORIES LIMITED (IN) | 2012-04-12 | — | — | WO | disclosed |
| WO-2012046247-A2 | PROCESS FOR THE PREPARATION OF (±M1R(S), 2SRR)L-2-(AMINOMETHYL)-N,N-DIETHYL-L-PHENYLCYCLOPROPANE CARBOXAMIDE HYDROCHLORIDE | MSN LABORATORIES LIMITED (IN) | 2012-04-12 | — | — | WO | disclosed |
| WO-2011158249-A1 | PROCESS FOR PREPARATION OF MILNACIPRAN INTERMEDIATE AND ITS USE IN PREPARATION OF PURE MILNACIPRAN | GLENMARK GENERICS LIMITED (IN) | 2011-12-22 | — | — | WO | disclosed |
| EP-1770084-B1 | METHOD FOR PRODUCING (Z)-1-PHENYL-1-DIETHYLAMINOCARBONYL-2-AMINOMETHYL CYCLOPROPANE HYDROCHLORIDE | SUMITOMO CHEMICAL CO (JP) | 2011-08-24 | — | — | EP | disclosed |
| US-20090292127-A1 | Process for Producing (Z)-1-Phenyl-1-(N,N-Diethylaminocarbonyl)-2-Phthalimidomethylcyclopropane | SUMITOMO CHEMICAL COMPANY, LIMITED | 2009-11-26 | — | — | US | disclosed |
| US-7592485-B2 | Process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethylcyclopropane hydrochloride | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-09-22 | — | — | US | disclosed |
| US-20080051604-A1 | Process For Producing (Z)-1-Phenyl-1-Diethylaminocarbonyl-2-Aminomethylcyclopropane Hydrochloride | SUMITOMO CHEMICAL COMPANY, LIMITED | 2008-02-28 | — | — | US | disclosed |
| CN-1972901-A | Method for producing (z)-1-phenyl-1-diethylaminocarbonyl-2-aminomethyl cyclopropane hydrochloride | SUMITOMO CHEMICAL CO (JP) | 2007-05-30 | — | — | CN | disclosed |
| EP-1770084-A1 | METHOD FOR PRODUCING (Z)-1-PHENYL-1-DIETHYLAMINOCARBONYL-2-AMINOMETHYL CYCLOPROPANE HYDROCHLORIDE | Sumitomo Chemical Company, Limited (JP) | 2007-04-04 | — | — | EP | disclosed |
| US-5034541-A | Method of preparing 1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethyl-cyclopropane-z | PIERRE FABRE MEDICAMENT (FR) | 1991-07-23 | — | — | US | disclosed |
| US-5034541-A | Method of preparing 1-phenyl-1-diethylaminocarbonyl-2-phthalimidomethyl-cyclopropane-z | PIERRE FABRE MEDICAMENT (FR) | 1991-07-23 | — | — | US | disclosed |
| EP-0377381-A1 | Process for the preparation of 1-phenyl-1-diethyl amino-carbonyl-2-phthalimide methyl cyclopropane Z | PIERRE FABRE MEDICAMENT (FR) | 1990-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090292127-A1 | Process for Producing (Z)-1-Phenyl-1-(N,N-Diethylaminocarbonyl)-2-Phthalimidomethylcyclopropane | BPNT1, CPN1, PNN | SLC6A2 2105/4885SLC6A4 2288/4885SLC6A3 1267/4885 |
| US-20080051604-A1 | Process For Producing (Z)-1-Phenyl-1-Diethylaminocarbonyl-2-Aminomethylcyclopropane Hydrochloride | PNMT, AZI2, AMD1 | SLC6A2 2947/4885SLC6A4 2494/4885SLC6A3 1477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.