Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.48 |
| ▸ | MCOLN1 | Q9GZU1 | 1/20 | 0.48 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12896515 | 1.00 | ALDH1A1 (0.64) | ALDH1A1DRD2TSHRMEN1KMT2A | |
| SCHEMBL12897275 | 0.92 | DRD2 (0.55) | ALDH1A1DRD2MEN1KMT2AHTR2C | |
| SCHEMBL12897089 | 0.92 | DRD2 (0.55) | ALDH1A1DRD2MEN1KMT2AHTR2C | |
| SCHEMBL12896502 | 0.87 | DRD2 (0.56) | ALDH1A1DRD2MEN1KMT2AHTR2C | |
| SCHEMBL12896451 | 0.87 | MEN1 (0.59) | DRD2MEN1KMT2AHTR2CMCOLN2 | |
| SCHEMBL12897136 | 0.86 | MEN1 (0.61) | DRD2MEN1KMT2AHTR2CMCOLN2 | |
| SCHEMBL12896742 | 0.86 | MEN1 (0.61) | DRD2MEN1KMT2AHTR2CMCOLN2 | |
| SCHEMBL7890862 | 0.86 | MEN1 (0.61) | DRD2MEN1KMT2AHTR2CMCOLN2 | |
| SCHEMBL12896884 | 0.85 | TRPV6 (0.56) | DRD2MEN1KMT2AHTR2CMCOLN2 | |
| Hydrochloric Acid SCHEMBL7879546 | 0.85 | MEN1 (0.60) | DRD2MEN1KMT2AHTR2CMCOLN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7880007-B2 | such as 1-bicyclo[2.2.1]hept-2-yl-4-(4-methoxy-2-methyl-phenyl)-piperidine, used for the treatment of chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects and Alzheimer's disease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |
| US-7880007-B2 | such as 1-bicyclo[2.2.1]hept-2-yl-4-(4-methoxy-2-methyl-phenyl)-piperidine, used for the treatment of chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects and Alzheimer's disease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |