Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12899158 | 1.00 | SIGMAR1 (0.33) | SIGMAR1MAP3K14OPRM1OPRL1KCNH2 | |
| SCHEMBL13640944 | 0.81 | MAP3K14 (0.34) | SIGMAR1MAP3K14OPRM1OPRL1KCNH2 | |
| SCHEMBL12899137 | 0.80 | CCR5 (0.32) | SIGMAR1OPRM1OPRL1LMNA | |
| SCHEMBL12899405 | 0.80 | OPRM1 (0.34) | SIGMAR1OPRM1OPRL1KCNH2 | |
| SCHEMBL12084406 | 0.79 | EBP (0.44) | SIGMAR1MAP3K14OPRM1OPRL1KCNH2 | |
| SCHEMBL3544623 | 0.77 | KDM4E (0.42) | — | |
| SCHEMBL3544620 | 0.77 | KDM4E (0.42) | — | |
| SCHEMBL12929039 | 0.77 | KDM4E (0.42) | — | |
| SCHEMBL12084140 | 0.77 | KDM4E (0.42) | — | |
| SCHEMBL13644057 | 0.74 | MAP3K14 (0.33) | SIGMAR1MAP3K14OPRM1OPRL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879834-B2 | spiro[indoline-3,4'-piperidine] derivatives, used for the treatment of nervous system disorders, chronic obstructive pulmonary disease, asthma, urinary incontinence, vision defects, Alzheimer's disiease, obesity or as analgesics and antidepressants | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-02-01 | — | — | US | disclosed |