Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.38 |
| ▸ | PDE4A | P27815 | 13/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.38 |
| ▸ | PDE5A | O76074 | 11/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.38 |
| ▸ | PDE1A | P54750 | 10/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 10/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 10/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 3/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 3/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.30 |
| ▸ | TUBB | P07437 | 1/20 | 0.30 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.30 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.30 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14930684 | 0.84 | CYP3A4 (0.49) | PDE4BPDE4APDE4CPDE4DCYP3A4 | |
| SCHEMBL128952 | 0.75 | KDM4E (0.40) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL128821 | 0.73 | CYP3A4 (0.39) | CYP3A4MAPT | |
| SCHEMBL14926967 | 0.71 | HPGD (0.37) | CYP3A4MAPT | |
| SCHEMBL129668 | 0.71 | PDE3B (0.48) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL195168 | 0.71 | CYP3A4 (0.56) | CYP3A4MAPT | |
| SCHEMBL127933 | 0.71 | CYP3A4 (0.45) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL14903992 | 0.69 | ACHE (0.36) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL127939 | 0.69 | CYP3A4 (0.43) | PDE4BPDE4APDE4CPDE4DPDE5A | |
| SCHEMBL14926968 | 0.67 | KDM4E (0.37) | PDE4BPDE4APDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9227966-B2 | Antimicrobial agents | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2016-01-05 | — | — | US | disclosed |
| US-8933096-B2 | Antimicrobial agents | Rugers, The State University of New Jersey (US) | 2015-01-13 | — | — | US | disclosed |
| US-20140315939-A1 | ANTIMICROBIAL AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2014-10-23 | — | — | US | disclosed |
| US-20130116278-A1 | ANTIMICROBIAL AGENTS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY | 2013-05-09 | — | — | US | disclosed |
| US-20120059026-A1 | ANTIMICROBIAL AGENTS | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116278-A1 | ANTIMICROBIAL AGENTS | MRPL21, ARG1, RPP30 | PDE4B 2021/4885PDE4A 2153/4885PDE4C 2006/4885 |
| US-20120059026-A1 | ANTIMICROBIAL AGENTS | ZYX, Q6ZSR9, ZC3HAV1L | PDE4B 1251/4885PDE4A 1469/4885PDE4C 2096/4885 |
| US-20140315939-A1 | ANTIMICROBIAL AGENTS | ZYX, Q6ZSR9, ZC3HAV1L | PDE4B 1783/4885PDE4A 1919/4885PDE4C 2456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.