Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13297796 | 0.80 | EHMT2 (0.49) | EHMT2SMOKMT2AALDH1A1MEN1 | |
| SCHEMBL14870544 | 0.74 | ALDH1A1 (0.62) | KMT2AALDH1A1KDM4EMAPTPKM | |
| SCHEMBL14870547 | 0.71 | ALDH1A1 (0.63) | KMT2AALDH1A1KDM4EMAPTPKM | |
| SCHEMBL4597179 | 0.70 | EHMT2 (0.49) | EHMT2SMOKMT2AALDH1A1MEN1 | |
| SCHEMBL102314 | 0.70 | EHMT2 (0.49) | EHMT2SMOKMT2AALDH1A1MEN1 | |
| SCHEMBL4187223 | 0.70 | EHMT2 (0.49) | EHMT2SMOKMT2AALDH1A1MEN1 | |
| SCHEMBL6300356 | 0.70 | EPHX2 (0.55) | KMT2AALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL20086223 | 0.69 | SMO (0.49) | EHMT2SMOKMT2AALDH1A1KDM4E | |
| SCHEMBL9766496 | 0.69 | MEN1 (0.60) | EHMT2SMOKMT2AALDH1A1MAPT | |
| SCHEMBL21563349 | 0.69 | GSK3A (0.53) | EHMT2SMOKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879838-B2 | Chemokine receptor antagonists used for the treatment of inflammatory diseases, autoimmune diseases, transplant rejection, infectious diseases, drug sensitivity, ophthalmic inflammation, type I diabetes, viral meningitis and tumors | SCHERING CORPORATION (US) | 2011-02-01 | — | — | US | disclosed |
| US-7879838-B2 | Chemokine receptor antagonists used for the treatment of inflammatory diseases, autoimmune diseases, transplant rejection, infectious diseases, drug sensitivity, ophthalmic inflammation, type I diabetes, viral meningitis and tumors | SCHERING CORPORATION (US) | 2011-02-01 | — | — | US | disclosed |