Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | MMP12 | P39900 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | AGXT | P21549 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12214521 | 1.00 | MMP2 (0.44) | MMP2MMP12MMP1MMP9NPC1 | |
| Toluene SCHEMBL27746059 | 0.89 | ANPEP (0.48) | CTSKCTSLALDH1A1ANPEP | |
| SCHEMBL12214484 | 0.86 | CYP3A4 (0.48) | MMP2MMP12MMP1MMP9RAB9A | |
| SCHEMBL355730 | 0.85 | ALDH1A1 (0.53) | CTSKCTSLALDH1A1TDP1L3MBTL1 | |
| SCHEMBL353695 | 0.85 | ALDH1A1 (0.53) | CTSKCTSLALDH1A1TDP1L3MBTL1 | |
| SCHEMBL728728 | 0.85 | ALDH1A1 (0.53) | CTSKCTSLALDH1A1TDP1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL9697973 | 0.84 | ALDH1A1 (0.51) | CTSKCTSLALDH1A1ANPEP | |
| Hydrochloric Acid SCHEMBL1810902 | 0.84 | ALDH1A1 (0.51) | CTSKCTSLALDH1A1ANPEP | |
| Hydrochloric Acid SCHEMBL7365467 | 0.84 | ALDH1A1 (0.51) | CTSKCTSLALDH1A1ANPEP | |
| SCHEMBL12238544 | 0.83 | SLC7A5 (0.37) | CTSKCTSLCA1CA2SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4112611-A2 | MODULATORS OF SESTRIN-GATOR2 INTERACTION AND USES THEREOF | Navitor Pharmaceuticals, Inc. (US) | 2023-01-04 | — | — | EP | disclosed |
| US-7893023-B2 | Prodrugs activated by plasmin and their use in cancer chemotherapy | MEDAREX, INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090076176-A1 | Prodrugs activated by plasmin and their use in cancer chemotherapy | MEDAREX, INC. (US) | 2009-03-19 | — | — | US | disclosed |
| US-7402556-B2 | Prodrugs activated by plasmin and their use in cancer chemotherapy | MEDAREX, INC. (US) | 2008-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076176-A1 | Prodrugs activated by plasmin and their use in cancer chemotherapy | PLG, PLAT, DNPEP | MMP2 56/4885MMP12 90/4885MMP1 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.