Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.67 |
| ▸ | BCR | P11274 | 11/20 | 0.67 |
| ▸ | PDGFRA | P16234 | 11/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.67 |
| ▸ | PRKCA | P17252 | 3/20 | 0.67 |
| ▸ | EGFR | P00533 | 2/20 | 0.67 |
| ▸ | ABL2 | P42684 | 2/20 | 0.65 |
| ▸ | JAK3 | P52333 | 1/20 | 0.62 |
| ▸ | BTK | Q06187 | 1/20 | 0.62 |
| ▸ | ITK | Q08881 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27841120 | 0.87 | ABL1 (0.79) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL13492488 | 0.84 | ABL1 (0.76) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL28812376 | 0.83 | PDGFRA (0.78) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL3219529 | 0.83 | ABL1 (0.77) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL13492322 | 0.82 | ABL1 (0.73) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL13492489 | 0.82 | ABL1 (0.75) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL4802851 | 0.82 | ABL1 (0.83) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL2004455 | 0.81 | PDGFRA (0.91) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL23246300 | 0.81 | ABL1 (0.86) | ABL1BCRPDGFRAPDGFRBPRKCA | |
| SCHEMBL13492334 | 0.81 | ABL1 (0.74) | ABL1BCRPDGFRAPDGFRBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011016861-A2 | NOVEL REGULATORY PROTEINS AND INHIBITORS | INTRA-CELLULAR THERAPIES, INC. (US) | 2011-02-10 | — | — | WO | disclosed |