Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3510989 | 0.86 | ALDH1A1 (0.37) | ESR1ESR2TDP1KDM4EALDH1A1 | |
| SCHEMBL1259292 | 0.81 | ESR1 (0.43) | ESR1ESR2TDP1ARKDM4E | |
| SCHEMBL8589226 | 0.81 | ALOX15 (0.40) | ESR1TDP1ARKDM4EALDH1A1 | |
| SCHEMBL19554054 | 0.81 | GFER (0.33) | ALDH1A1KMT2ASMN1; SMN2MEN1ALOX15 | |
| SCHEMBL11768389 | 0.79 | LMNA (0.36) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL2082910 | 0.78 | MEN1 (0.41) | TDP1KDM4EALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL17601115 | 0.78 | CYP3A4 (0.38) | TDP1KDM4EALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL3512335 | 0.78 | TDP1 (0.44) | TDP1KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL11001481 | 0.78 | SMN1; SMN2 (0.49) | TDP1TP53KDM4EALDH1A1KMT2A | |
| SCHEMBL1530165 | 0.76 | ESR1 (0.39) | ESR1ESR2TP53ARKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8946437-B2 | 4-(methylaminophenoxy)pyrdin-3-yl-benzamide derivatives for treating cancer | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2015-02-03 | — | — | US | disclosed |