Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.59 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.59 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.59 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.59 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 5/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907451 | 0.86 | FGFR1 (0.70) | MAPK1MAP2K4MAPKAPK2MAPK6MAPKAPK3 | |
| SCHEMBL19188029 | 0.86 | JAK2 (0.57) | MAPK1MAP2K4MAPKAPK2MAPK6MAPKAPK3 | |
| SCHEMBL23062796 | 0.85 | MAP2K4 (0.53) | MAPK1MAP2K4MAPKAPK2MAPK6MAPKAPK3 | |
| SCHEMBL12907433 | 0.85 | MKNK1 (0.51) | MAPK1MAP2K4MAPKAPK2MAPK6MAPKAPK3 | |
| SCHEMBL27968550 | 0.84 | MKNK1 (0.71) | MAP2K4JAK2MKNK1PRKAG1PRKAA1 | |
| SCHEMBL10213932 | 0.81 | JAK2 (0.72) | MAPK1MAP2K4MAPKAPK2MAPK6MAPKAPK3 | |
| SCHEMBL22513706 | 0.80 | JAK2 (0.51) | JAK2MKNK1PDPK1PRKAG1PRKAA1 | |
| SCHEMBL22339348 | 0.80 | JAK2 (0.51) | JAK2MKNK1PDPK1PRKAG1PRKAA1 | |
| SCHEMBL22513720 | 0.79 | JAK2 (0.50) | JAK2MKNK1PDPK1PRKAG1PRKAA1 | |
| SCHEMBL12907440 | 0.78 | JAK2 (0.48) | MAPK1MAP2K4MAPKAPK2MAPK6MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |