Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | MAP2K4 | P45985 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | MAPKAPK3 | Q16644 | 4/20 | 0.50 |
| ▸ | MAPK6 | Q16659 | 4/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.50 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27968550 | 0.87 | MKNK1 (0.71) | JAK2MKNK1MAP2K4PRKAG1PRKAA1 | |
| SCHEMBL12907439 | 0.86 | MAPK1 (0.59) | JAK2MKNK1MAP2K4MAPK1MAPKAPK3 | |
| SCHEMBL14397096 | 0.85 | PDPK1 (0.53) | JAK2MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL12222 | 0.84 | MAP2K4 (0.57) | JAK2MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL29769133 | 0.84 | MAP2K4 (0.57) | JAK2MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL12907187 | 0.84 | JAK2 (0.72) | JAK2PDPK1CDC7PLK4DAPK3 | |
| SCHEMBL22339348 | 0.83 | JAK2 (0.51) | JAK2MKNK1PDPK1PRKAG1PRKAA1 | |
| SCHEMBL22513706 | 0.83 | JAK2 (0.51) | JAK2MKNK1PDPK1ADORA2AADORA2B | |
| SCHEMBL22513720 | 0.82 | JAK2 (0.50) | JAK2MKNK1PDPK1PRKAG1PRKAA1 | |
| SCHEMBL12907433 | 0.78 | MKNK1 (0.51) | JAK2MKNK1MAP2K4MAPK1MAPKAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019070943-A1 | SMALL MOLECULE INHIBITION OF TRANSCRIPTION FACTOR SALL4 AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-04-11 | — | — | WO | disclosed |
| EP-2758398-B1 | SUBSTITUTED N- [1-CYANO-2- (PHENYL) ETHYL]-2-AZABICYCLO [2.2.1]HEPTANE-3-CARBOXAMIDE INHIBITORS OF CATHEPSIN C | BOEHRINGER INGELHEIM INT (DE) | 2017-08-02 | — | — | EP | disclosed |