Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.48 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.48 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12907435 | 0.88 | CHEK1 (0.58) | HSD17B1HSD17B2CYP3A4CYP2C9CHEK1 | |
| SCHEMBL12907439 | 0.85 | MAPK1 (0.59) | MKNK1CHEK1MAP2K4MAPK1MAPKAPK2 | |
| SCHEMBL27968550 | 0.83 | MKNK1 (0.71) | MKNK1CHEK1MAP2K4JAK2GSK3B | |
| SCHEMBL10213901 | 0.83 | JAK2 (0.71) | HSD17B1HSD17B2CYP3A4CYP2C9CHEK1 | |
| SCHEMBL23062796 | 0.81 | MAP2K4 (0.53) | CYP3A4CYP2C9MAP2K4MAPK1MAPKAPK2 | |
| SCHEMBL21509969 | 0.80 | MAP2K4 (0.60) | MKNK1MAP2K4MAPK1MAPKAPK3MAPK6 | |
| SCHEMBL19188029 | 0.78 | JAK2 (0.57) | MKNK1MAP2K4MAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL29942349 | 0.78 | MAP2K4 (0.64) | MKNK1CHEK1MAP2K4JAK2GSK3B | |
| SCHEMBL12907440 | 0.77 | JAK2 (0.48) | MKNK1MAP2K4MAPK1MAPKAPK2MAPKAPK3 | |
| SCHEMBL12907599 | 0.76 | CHEK1 (0.59) | HSD17B1HSD17B2CHEK1DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872039-B2 | N-3-chlorobenzyl-3-amino-1H-indazole-5-carboxamide; 3-aminoindazoles; glucocorticoid-depedent kinase (SGK) inhibitors; SGK-induced diseases; diabetes, obesity, metabolic syndrome (dyslipidaemia), systemic and pulmonary hypertonia, cardiovascular diseases and renal diseases, fibrosis; inflammatory agents | MERCK PATENT GESELLSCHAFT (DE) | 2011-01-18 | — | — | US | disclosed |