Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1290859 | 0.82 | SMYD3 (0.38) | ALDH1A1MAPTMEN1KMT2ASMYD3 | |
| SCHEMBL1290611 | 0.80 | SMYD3 (0.38) | MEN1KMT2ASMYD3 | |
| SCHEMBL7982185 | 0.77 | MEN1 (0.48) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1290996 | 0.68 | HDAC2 (0.48) | MAPTMEN1KMT2A | |
| SCHEMBL578342 | 0.62 | SMYD3 (0.61) | SMYD3 | |
| SCHEMBL29642948 | 0.62 | SMYD3 (0.61) | SMYD3 | |
| SCHEMBL30950742 | 0.61 | RAB9A (0.37) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2295986 | 0.61 | RAB9A (0.37) | ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL28552531 | 0.60 | AHR (0.50) | MAPTMEN1KMT2A | |
| SCHEMBL3060475 | 0.60 | ACVRL1 (0.34) | ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012045194-A1 | BENZODIAZEPINONES AS FAK INHIBITORS FOR TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2012-04-12 | — | — | WO | disclosed |