Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | FER | P16591 | 1/20 | 0.32 |
| ▸ | LTK | P29376 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 4/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503704 | 0.82 | CHEK1 (0.38) | MEN1KMT2AMAPTAHRMAPK13 | |
| SCHEMBL1290778 | 0.79 | SMYD3 (0.36) | MEN1KMT2ABRD4MAPK14 | |
| SCHEMBL28552531 | 0.77 | AHR (0.50) | MEN1KMT2AKDM4EMAPTBRD4 | |
| SCHEMBL28517190 | 0.75 | PDGFRA (0.35) | MEN1KMT2ABRPF1PDGFRAFER | |
| SCHEMBL8590983 | 0.75 | ACVR1 (0.44) | MEN1KMT2APDGFRAFERLTK | |
| SCHEMBL2143931 | 0.72 | GAA (0.45) | MEN1KMT2ABRPF1MAPT | |
| SCHEMBL20525381 | 0.72 | MEN1 (0.35) | MEN1KMT2AALDH1A1BRPF1MAPT | |
| SCHEMBL8201662 | 0.71 | BRD4 (0.43) | MEN1KMT2AALDH1A1BRPF1KDM4E | |
| SCHEMBL10969348 | 0.70 | HTR5A (0.41) | MEN1KMT2AKDM4EMAPTBRD4 | |
| SCHEMBL29483964 | 0.68 | AHR (0.50) | MEN1KMT2AALDH1A1BRPF1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235730-B1 | ANTICHOLESTEROL AGENT, ANTILIPEMIC AGENT | JAPAN TOBACCO, INC. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0970954-A1 | 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME | JAPAN TOBACCO INC. (JP) | 2000-01-12 | — | — | EP | disclosed |