⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28229251 | 1.00 | — | — | |
| Ammonia Solution, Strong SCHEMBL27793753 | 0.95 | — | — | |
| SCHEMBL3103249 | 0.80 | — | — | |
| SCHEMBL21263656 | 0.78 | NOS2 (0.44) | — | |
| SCHEMBL14131007 | 0.78 | NOS2 (0.44) | — | |
| SCHEMBL292535 | 0.77 | — | — | |
| SCHEMBL7350898 | 0.74 | — | — | |
| SCHEMBL12821996 | 0.74 | — | — | |
| SCHEMBL2976691 | 0.73 | — | — | |
| SCHEMBL24866428 | 0.72 | AKT2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 295 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11673883-B2 | Heterocyclic compounds as immunomodulators | INCYTE CORPORATION (US) | 2023-06-13 | — | — | US | claimed |
| CN-114075174-A | Heat-resistant explosive and synthesis method thereof | 南京理工大学 | 2022-02-22 | — | — | CN | claimed |
| EP-3464279-B1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORP (US) | 2021-11-24 | — | — | EP | claimed |
| EP-3464279-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | Incyte Corporation (US) | 2019-04-10 | — | — | EP | claimed |
| CN-105143207-B | Substituted pyridine and substituted pyrazine compounds as PDE4 inhibitors | 达特神经科学(开曼)有限公司 | 2018-04-24 | — | — | CN | claimed |
| CN-107935929-A | 3 trifluoromethyl 1H pyrazoles of a kind of 1 methyl, 4 amide derivatives and preparation method and application | 浙江工业大学 | 2018-04-20 | — | — | CN | claimed |
| US-20170342060-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION | 2017-11-30 | — | — | US | claimed |
| WO-2017205464-A1 | HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2017-11-30 | — | — | WO | claimed |
| EP-3050873-B1 | SULFUR DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | ALLERGAN INC (US) | 2017-09-13 | — | — | EP | claimed |
| CN-107033084-A | A kind of acyl urea compound for containing 1,3 dimethyl 1H pyrrazole structures and its preparation method and application | 浙江工业大学 | 2017-08-11 | — | — | CN | claimed |
| CN-101421257-A | Agents that disrupt cellular replication and their use in inhibiting pathological conditions | EUROPEAN MOLECULAR BIOLOGY LAB EMBL (DE) | 2009-04-29 | — | — | CN | claimed |
| WO-2007107352-A1 | AGENTS THAT DISRUPT CELLULAR REPLICATION AND THEIR USE IN INHIBITING PATHOLOGICAL CONDITIONS | THE EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2007-09-27 | — | — | WO | claimed |
| US-6969728-B2 | Antiinflammatory agents | GENZYME CORPORATION (US) | 2005-11-29 | — | — | US | claimed |
| EP-1567138-A1 | USE OF DIAMIDE DERIVATIVES FOR INHIBITING CHRONIC TISSUE TRANSPLANT REJECTION | Genzyme Corporation (US) | 2005-08-31 | — | — | EP | claimed |
| US-20040163654-A1 | Inhibition of chronic tissue transplant rejection | GENZYME CORPORATION | 2004-08-26 | — | — | US | claimed |
| WO-2004047825-A1 | USE OF DIAMIDE DERIVATIVES FOR INHIBITING CHRONIC TISSUE TRANSPLANT REJECTION | GENZYME CORPORATION (US) | 2004-06-10 | — | — | WO | claimed |
| CN-1441787-A | Modulators of TNF-alpha signaling | GENZYME CORP (US) | 2003-09-10 | — | — | CN | claimed |
| EP-1294699-A2 | MODULATORS OF TNF- ALPHA SIGNALLING | GENZYME CORPORATION (US) | 2003-03-26 | — | — | EP | claimed |
| US-20020119988-A1 | Antiinflammatory agents | GENZYME CORPORATION | 2002-08-29 | — | — | US | claimed |
| WO-2001087849-A2 | MODULATORS OF TNF- ALPHA SIGNALING | GENZYME CORPORATION (US) | 2001-11-22 | — | — | WO | claimed |