SCHEMBL12911701

SCHEMBL12911701

COC(=O)N(NC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl)C(C)=O

nearest known ligand 0.57

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 3/20 0.34
▸ DHODH Q02127 1/20 0.33
▸ F10 P00742 5/20 0.33
▸ MALT1 Q9UDY8 2/20 0.32
▸ KLKB1 P03952 1/20 0.32
▸ TRPV1 Q8NER1 1/20 0.32
▸ RBP4 P02753 2/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ OPRL1 P41146 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13072869 0.96 PDE4B (0.35) PDE4BDHODHF10MALT1KLKB1
SCHEMBL12911699 0.92 DHODH (0.36) PDE4BDHODHF10TRPV1RBP4
SCHEMBL12527872 0.90 KMT2A (0.35) DHODHF10MALT1RBP4MEN1
SCHEMBL12527842 0.89 DHODH (0.40) DHODHF10MALT1RBP4
SCHEMBL13318569 0.88 DHODH (0.37) PDE4BDHODHF10TRPV1RBP4
SCHEMBL12911702 0.87 DHODH (0.36) PDE4BDHODHF10KLKB1TRPV1
SCHEMBL17205056 0.87 PDE4B (0.38) PDE4BDHODHF10MALT1TRPV1
SCHEMBL13209133 0.86 PDE4B (0.41) PDE4BDHODHF10MALT1KLKB1
SCHEMBL782368 0.86 CARM1 (0.39) PDE4BF10MALT1KLKB1TRPV1
SCHEMBL13318514 0.85 PDE4B (0.38) PDE4BDHODHF10MALT1TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT PDE4B 275/4885DHODH 284/4885F10 3713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback