SCHEMBL782368

SCHEMBL782368

CNC(=O)c1cc(Cl)cc(C)c1NC(=O)c1cc(C(F)(F)F)nn1-c1ncccc1Cl

nearest known ligand 0.76

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CARM1 Q86X55 1/20 0.39
PDE4B Q07343 2/20 0.37
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.36
MALT1 Q9UDY8 2/20 0.36
TRPV1 Q8NER1 2/20 0.36
F10 P00742 1/20 0.36
STIM1 Q13586 1/20 0.35
ORAI1 Q96D31 1/20 0.35
KLKB1 P03952 2/20 0.35
TGFBR1 P36897 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3679335 0.94 PDE4B (0.37) CARM1PDE4BKDM4EMEN1ALDH1A1
SCHEMBL10140166 0.94 CARM1 (0.38) CARM1PDE4BKDM4EMEN1ALDH1A1
SCHEMBL12911856 0.93 CARM1 (0.39) CARM1PDE4BKDM4EMEN1ALDH1A1
SCHEMBL25702787 0.93 TRPV1 (0.39) CARM1PDE4BKDM4EMEN1ALDH1A1
SCHEMBL782241 0.93 CARM1 (0.40) CARM1PDE4BKDM4EMEN1ALDH1A1
SCHEMBL12911546 0.93 NOTUM (0.37) CARM1PDE4BKDM4EMEN1ALDH1A1
SCHEMBL14434285 0.92 CARM1 (0.39) CARM1PDE4BKDM4EMEN1ALDH1A1
SCHEMBL951313 0.92 KLKB1 (0.38) CARM1PDE4BKDM4EMEN1ALDH1A1
SCHEMBL13209133 0.92 PDE4B (0.41) CARM1PDE4BKDM4EMEN1ALDH1A1
SCHEMBL17205424 0.92 PDE4B (0.37) CARM1PDE4BKDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 221 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS ANNAN ISSAC BILLY 2009-03-19 US claimed
US-20210378242-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2021-12-09 US disclosed
US-10405548-B2 Fungicidal compositions SYNGENTA CROP PROTECTION LLC (US) 2019-09-10 US disclosed
EP-2547665-B1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-07-04 EP disclosed
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2018-06-21 US disclosed
US-9949482-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2018-04-24 US disclosed
US-9826737-B2 Solid formulations of carboxamide arthropodicides E I DU PONT DE NEMOURS AND COMPANY (US) 2017-11-28 US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 US disclosed
US-20170215419-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE E I DUPONT DE NEMOURS AND COMPANY 2017-08-03 US disclosed
WO-2007068356-A1 INSECTICIDAL COMPOSITIONS WITH IMPROVED EFFECT BAYER CROPSCIENCE AG (DE) 2007-06-21 WO disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 US disclosed
US-7232836-B2 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides E. I. DU PONT DE NEMOURS AND COMPANY (US) 2007-06-19 US disclosed
WO-2007020050-A2 BICYCLIC BISAMIDE DERIVATIVES AND USE THEREOF AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2007-02-22 WO disclosed
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds E. I. DU PONT DE NEMOURS AND COMPANY 2005-04-07 US disclosed
US-20040209923-A1 Anthranilamide arthropodicide treatment FMC CORPORATION 2004-10-21 US disclosed
US-20040198984-A1 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides FMC CORPORATION 2004-10-07 US disclosed
US-20040110777-A1 Quinazolinones and pyridinylpyrimidinones for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY 2004-06-10 US disclosed
EP-1416797-A1 ARTHROPODICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-05-12 EP disclosed
WO-2003015519-A1 ARTHROPODICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210378242-A1 FUNGICIDAL COMPOSITIONS PIK3C3, CYP51A1, CYP1B1 CARM1 2370/4885PDE4B 262/4885KDM4E 1678/4885
US-20070142327-A1 Active compound combinations having insecticidal properties ACHE, ANTXR2, NANP CARM1 1638/4885PDE4B 66/4885KDM4E 1149/4885
US-20040110777-A1 Quinazolinones and pyridinylpyrimidinones for controlling invertebrate pests SYNJ1, SBK3, KCNK4 CARM1 4363/4885PDE4B 695/4885KDM4E 858/4885
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS NASP, CPS1, CYP11A1 CARM1 1166/4885PDE4B 1470/4885KDM4E 1360/4885
US-20040209923-A1 Anthranilamide arthropodicide treatment ANTXR2, ARF5, NPM1 CARM1 1006/4885PDE4B 2518/4885KDM4E 3875/4885
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE AADAC, ABL2, API5 CARM1 3483/4885PDE4B 2427/4885KDM4E 1556/4885
US-20040198984-A1 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides CYP4B1, CYP1B1, CYP2E1 CARM1 1207/4885PDE4B 908/4885KDM4E 1504/4885
US-10405548-B2 Fungicidal compositions PIK3C3, CYP51A1, CYP1B1 CARM1 2370/4885PDE4B 262/4885KDM4E 1678/4885
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds ANTXR2, HRH4, HDAC10 CARM1 417/4885PDE4B 937/4885KDM4E 276/4885
US-20170215419-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE AADAC, ABL2, API5 CARM1 3483/4885PDE4B 2427/4885KDM4E 1556/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.