SCHEMBL12911905

SCHEMBL12911905

Cc1cc(Cl)c2nc(-c3cc(C(F)(F)F)nn3-c3ncccc3Cl)oc(=O)c2c1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ PTGS2 P35354 3/20 0.35
▸ PTGS1 P23219 2/20 0.35
▸ RXRA P19793 3/20 0.34
▸ NR1H2 P55055 3/20 0.34
▸ NR1H3 Q13133 3/20 0.34
▸ CARM1 Q86X55 1/20 0.34
▸ MAPT P10636 2/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ OPRL1 P41146 1/20 0.33
▸ PDPK1 O15530 2/20 0.32
▸ NR3C2 P08235 1/20 0.32
▸ DHODH Q02127 2/20 0.32
▸ ELANE P08246 1/20 0.32
▸ TRPV1 Q8NER1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL950884 0.94 KDM4E (0.34) KDM4EL3MBTL1PTGS2PTGS1RXRA
SCHEMBL12911874 0.92 KDM4E (0.33) KDM4EL3MBTL1PTGS2PTGS1RXRA
SCHEMBL950404 0.92 DHODH (0.34) KDM4EL3MBTL1PTGS2PTGS1RXRA
SCHEMBL14495253 0.91 KDM4E (0.33) KDM4EL3MBTL1PTGS2PTGS1RXRA
SCHEMBL950826 0.91 KDM4E (0.36) KDM4EL3MBTL1PTGS2PTGS1RXRA
SCHEMBL950425 0.89 KDM4E (0.37) KDM4EL3MBTL1PTGS2PTGS1RXRA
SCHEMBL951078 0.89 DHODH (0.34) KDM4EL3MBTL1PTGS2PTGS1RXRA
SCHEMBL25235198 0.88 MAPT (0.35) KDM4EL3MBTL1PTGS2PTGS1RXRA
SCHEMBL499517 0.88 KDM4E (0.34) KDM4EL3MBTL1PTGS2PTGS1RXRA
SCHEMBL30466609 0.88 MAPT (0.35) KDM4EL3MBTL1PTGS2PTGS1RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT KDM4E 2028/4885L3MBTL1 2293/4885PTGS2 903/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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