SCHEMBL950826

SCHEMBL950826

O=c1oc(-c2cc(C(F)(F)F)nn2-c2ncccc2Cl)nc2c(Cl)cc(Cl)cc12

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ PTGS2 P35354 6/20 0.36
▸ PTGS1 P23219 4/20 0.36
▸ MAPT P10636 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ PDPK1 O15530 3/20 0.33
▸ RXRA P19793 2/20 0.33
▸ NR1H2 P55055 2/20 0.33
▸ NR1H3 Q13133 2/20 0.33
▸ CARM1 Q86X55 1/20 0.33
▸ NR3C2 P08235 1/20 0.33
▸ HSD11B1 P28845 1/20 0.32
▸ C1R P00736 1/20 0.31
▸ DHODH Q02127 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL499517 0.92 KDM4E (0.34) KDM4EL3MBTL1PTGS2PTGS1MAPT
SCHEMBL950450 0.92 KDM4E (0.34) KDM4EL3MBTL1PTGS2PTGS1MAPT
SCHEMBL12911905 0.91 KDM4E (0.35) KDM4EL3MBTL1PTGS2PTGS1MAPT
SCHEMBL950425 0.90 KDM4E (0.37) KDM4EL3MBTL1PTGS2PTGS1MAPT
SCHEMBL535651 0.88 KDM4E (0.35) KDM4EL3MBTL1PTGS2PTGS1MAPT
SCHEMBL950708 0.87 KDM4E (0.35) KDM4EL3MBTL1PTGS2PTGS1MAPT
SCHEMBL950869 0.87 C1R (0.43) KDM4EL3MBTL1PTGS2PTGS1MAPT
SCHEMBL2936337 0.87 PTGS2 (0.33) KDM4EL3MBTL1PTGS2PTGS1MAPT
SCHEMBL25235198 0.86 MAPT (0.35) KDM4EL3MBTL1PTGS2PTGS1MAPT
SCHEMBL950884 0.86 KDM4E (0.34) KDM4EL3MBTL1PTGS2PTGS1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2742037-B1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2015-10-14 — — EP disclosed
US-9044016-B2 N-thio-anthranilamide compounds and their use as pesticides BASF SE (DE) 2015-06-02 — — US disclosed
EP-2742037-A1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2014-06-18 — — EP disclosed
US-20140154180-A1 Pharmacophores for Amyloid Fibers Involved in Alzheimer's Disease THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-06-05 — — US disclosed
US-20140155264-A1 N-Thio-Anthranilamide Compounds and Their Use as Pesticides BASF SE (DE) 2014-06-05 — — US disclosed
WO-2013024009-A1 N-THIO-ANTHRANILAMIDE COMPOUNDS AND THEIR USE AS PESTICIDES BASF SE (DE) 2013-02-21 — — WO disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 — — US disclosed
US-7968573-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-06-28 — — US disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 — — EP disclosed
EP-1937664-B1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2011-06-15 — — EP disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME IKEGAMI HIROSHI 2011-03-24 — — US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
US-7867949-B2 Hydrazide compound and pesticidal use of the same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-11 — — US disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 — — EP disclosed
EP-2251336-A1 Hydrazide compounds as intermediates of pesticides Sumitomo Chemical Company, Limited (JP) 2010-11-17 — — EP disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2009-07-16 — — US disclosed
WO-2007043677-A9 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL CO (JP) 2007-06-07 — — WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071291-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME ACHE, H1-2, H1-0 KDM4E 1084/4885L3MBTL1 852/4885PTGS2 801/4885
US-20140155264-A1 N-Thio-Anthranilamide Compounds and Their Use as Pesticides NAT1, ANTXR2, ATL3 KDM4E 4231/4885L3MBTL1 59/4885PTGS2 1123/4885
US-20090181956-A1 Hydrazide Compound and Pesticidal Use of the Same ACHE, DDT, CAT KDM4E 2028/4885L3MBTL1 2293/4885PTGS2 903/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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