SCHEMBL499517

SCHEMBL499517

Cc1cc(Cl)cc2c(=O)oc(-c3cc(C(F)(F)F)nn3-c3ncccc3Cl)nc12

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ MAPT P10636 2/20 0.33
▸ ELANE P08246 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ OPRL1 P41146 1/20 0.33
▸ RXRA P19793 2/20 0.33
▸ NR1H2 P55055 2/20 0.33
▸ NR1H3 Q13133 2/20 0.33
▸ PTGS2 P35354 3/20 0.32
▸ PTGS1 P23219 2/20 0.32
▸ CARM1 Q86X55 1/20 0.32
▸ DHODH Q02127 1/20 0.32
▸ CYP17A1 P05093 1/20 0.32
▸ CYP1A2 P05177 1/20 0.32
▸ NR3C2 P08235 2/20 0.32
▸ NR3C1 P04150 1/20 0.32
▸ PGR P06401 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12062854 0.94 ELANE (0.36) KDM4EL3MBTL1MAPTELANEMEN1
SCHEMBL25235198 0.93 MAPT (0.35) KDM4EL3MBTL1MAPTELANEMEN1
SCHEMBL950884 0.93 KDM4E (0.34) KDM4EL3MBTL1MAPTELANEMEN1
SCHEMBL30466609 0.93 MAPT (0.35) KDM4EL3MBTL1MAPTELANEMEN1
SCHEMBL30466601 0.92 MAPT (0.35) KDM4EL3MBTL1MAPTELANEMEN1
SCHEMBL950989 0.92 KDM4E (0.34) KDM4EL3MBTL1MAPTELANEMEN1
Ammonia Solution, Strong SCHEMBL25275402 0.92 MAPT (0.35) KDM4EL3MBTL1MAPTELANEMEN1
SCHEMBL950826 0.92 KDM4E (0.36) KDM4EL3MBTL1MAPTMEN1ALDH1A1
SCHEMBL951078 0.91 DHODH (0.34) KDM4EL3MBTL1MAPTELANEMEN1
SCHEMBL950940 0.90 ELANE (0.45) KDM4EL3MBTL1MAPTELANEMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9445593-B1 Arthropodicidal anthranilamides E I DU PONT DE NEMOURS AND COMPANY (US) 2016-09-20 — — US disclosed
US-20160255835-A1 ARTHROPODICIDAL ANTHRANILAMIDES FMC CORPORATION 2016-09-08 — — US disclosed
EP-2256112-B1 Anthranilamides, process for the production thereof and pest controllers containing the same ISHIHARA SANGYO KAISHA (JP) 2016-01-13 — — EP disclosed
US-9173400-B2 Anthranilamide arthropodicide treatment E I DU PONT DE NEMOURS AND COMPANY (US) 2015-11-03 — — US disclosed
US-9113630-B2 Method of controlling particular insect pests by applying anthranilamide compounds E I DU PONT DE NEMOURS AND COMPANY (US) 2015-08-25 — — US disclosed
US-9084422-B2 Anthranilamides compositions E I DU PONT DE NEMOURS AND COMPANY (US) 2015-07-21 — — US disclosed
US-9078437-B2 Arthropodicidal anthranilamides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-07-14 — — US disclosed
US-9049861-B2 Arthropodicidal anthranilamides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-06-09 — — US disclosed
US-9049862-B2 Arthropodicidal anthranilamides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-06-09 — — US disclosed
US-9029365-B2 Arthropodicidal anthranilamides E I DU PONT DE NEMOURS AND COMPANY (US) 2015-05-12 — — US disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 — — WO disclosed
WO-2007043677-A1 HYDRAZIDE COMPOUND AND PESTICIDAL USE OF THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-04-19 — — WO disclosed
EP-1717237-A1 ANTHRANILAMIDES, PROCESS FOR THE PRODUCTION THEREOF, AND PEST CONTROLLERS CONTAINING THE SAME ISHIHARA SANGYO KAISHA, LTD. (JP) 2006-11-02 — — EP disclosed
WO-2006061200-A1 ANTHRANILAMIDE DERIVATIVES AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2006-06-15 — — WO disclosed
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds E. I. DU PONT DE NEMOURS AND COMPANY 2005-04-07 — — US disclosed
US-20040209923-A1 Anthranilamide arthropodicide treatment FMC CORPORATION 2004-10-21 — — US disclosed
US-20040198984-A1 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides FMC CORPORATION 2004-10-07 — — US disclosed
US-20040110777-A1 Quinazolinones and pyridinylpyrimidinones for controlling invertebrate pests E. I. DU PONT DE NEMOURS AND COMPANY 2004-06-10 — — US disclosed
EP-1416797-A1 ARTHROPODICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-05-12 — — EP disclosed
WO-2003015519-A1 ARTHROPODICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110777-A1 Quinazolinones and pyridinylpyrimidinones for controlling invertebrate pests SYNJ1, SBK3, KCNK4 KDM4E 858/4885L3MBTL1 1049/4885MAPT 4468/4885
US-20040209923-A1 Anthranilamide arthropodicide treatment ANTXR2, ARF5, NPM1 KDM4E 3875/4885L3MBTL1 2037/4885MAPT 3919/4885
US-20040198984-A1 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides CYP4B1, CYP1B1, CYP2E1 KDM4E 1504/4885L3MBTL1 327/4885MAPT 4703/4885
US-20050075372-A1 Method for controlling particular insect pest by applying anthranilamide compounds ANTXR2, HRH4, HDAC10 KDM4E 276/4885L3MBTL1 686/4885MAPT 4874/4885
US-20160255835-A1 ARTHROPODICIDAL ANTHRANILAMIDES ANTXR2, NIT2, NAAA KDM4E 1491/4885L3MBTL1 859/4885MAPT 4869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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