SCHEMBL12912367

SCHEMBL12912367

CC(C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1ccc2ccccc2c1)C(N)=O

nearest known ligand 0.67

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ KISS1R Q969F8 6/20 0.62
▸ GHSR Q92847 5/20 0.62
▸ NPY1R P25929 3/20 0.59
▸ NPY2R P49146 3/20 0.59
▸ NPY4R P50391 3/20 0.59
▸ UTS2R Q9UKP6 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29706289 1.00 KISS1R (0.62) KISS1RGHSRNPY1RNPY2RNPY4R
SCHEMBL31404052 0.95 GHSR (0.68) KISS1RGHSRNPY1RNPY2RNPY4R
Acetic Acid SCHEMBL29757019 0.92 IL23R (0.59) UTS2R
Acetic Acid SCHEMBL29377757 0.92 IL23R (0.59) UTS2R
SCHEMBL29550957 0.91 KISS1R (0.64) KISS1RGHSRNPY1RNPY2RNPY4R
SCHEMBL29550946 0.91 KISS1R (0.64) KISS1RGHSRNPY1RNPY2RNPY4R
SCHEMBL30710492 0.91 IL23R (0.59) UTS2R
SCHEMBL7103421 0.91 IL23R (0.59) UTS2R
SCHEMBL14817785 0.91 IL23R (0.59) UTS2R
SCHEMBL14509563 0.91 GHSR (0.65) KISS1RGHSRNPY1RNPY2RNPY4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110003749-A2 USE OF SOMATOSTATIN OR ONE OF ITS ANALOGUES FOR PREPARING A MEDICAMENT INTENDED TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN PREGLEM S.A. (CH) 2011-01-06 — — US disclosed
US-20110003749-A2 USE OF SOMATOSTATIN OR ONE OF ITS ANALOGUES FOR PREPARING A MEDICAMENT INTENDED TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN PREGLEM S.A. (CH) 2011-01-06 — — US disclosed
US-20100152102-A1 USE OF SOMATOSTATIN OR ONE OF ITS ANALOGUES FOR PREPARING A MEDICAMENT INTENDED TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN PREGLEM S.A. (CH) 2010-06-17 — — US disclosed
US-20100152102-A1 USE OF SOMATOSTATIN OR ONE OF ITS ANALOGUES FOR PREPARING A MEDICAMENT INTENDED TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN PREGLEM S.A. (CH) 2010-06-17 — — US disclosed
US-7648961-B2 Accelerating the start of growth of quiescent follicles in non-menopausat women by administering somatostatin antagonist analog; reduces the risk of early menopause by preventing the accelerated activation of the follicular reserve which would make it more sensitive to chemotherapy agents or to radiation PREGLEM S.A. (CH) 2010-01-19 — — US disclosed
US-7648961-B2 Accelerating the start of growth of quiescent follicles in non-menopausat women by administering somatostatin antagonist analog; reduces the risk of early menopause by preventing the accelerated activation of the follicular reserve which would make it more sensitive to chemotherapy agents or to radiation PREGLEM S.A. (CH) 2010-01-19 — — US disclosed
US-20070155659-A1 Use of somatostatin or one of its analogues for preparing a medicament intended to regulate the ovarian follicular reserve in non-menopausal women SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION (FR) 2007-07-05 — — US disclosed
US-20070155659-A1 Use of somatostatin or one of its analogues for preparing a medicament intended to regulate the ovarian follicular reserve in non-menopausal women SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATION (FR) 2007-07-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100152102-A1 USE OF SOMATOSTATIN OR ONE OF ITS ANALOGUES FOR PREPARING A MEDICAMENT INTENDED TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN FSHR, GNRHR, SSTR3 KISS1R 22/4885GHSR 10/4885NPY1R 34/4885
US-20070155659-A1 Use of somatostatin or one of its analogues for preparing a medicament intended to regulate the ovarian follicular reserve in non-menopausal women FSHR, GNRHR, SSTR3 KISS1R 22/4885GHSR 10/4885NPY1R 34/4885
US-20110003749-A2 USE OF SOMATOSTATIN OR ONE OF ITS ANALOGUES FOR PREPARING A MEDICAMENT INTENDED TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN FSHR, GNRHR, SSTR3 KISS1R 22/4885GHSR 10/4885NPY1R 34/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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