Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.64 |
| ▸ | PRKAG1 | P54619 | 9/20 | 0.60 |
| ▸ | PRKAA2 | P54646 | 9/20 | 0.60 |
| ▸ | PRKAB1 | Q9Y478 | 9/20 | 0.60 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.55 |
| ▸ | CDC25A | P30304 | 8/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1060876 | 0.91 | TRPA1 (0.77) | KMT2ATRPA1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL1060878 | 0.91 | TRPA1 (0.77) | KMT2ATRPA1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL1061275 | 0.88 | TRPA1 (0.83) | KMT2ATRPA1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL1061274 | 0.88 | TRPA1 (0.83) | KMT2ATRPA1PRKAG1PRKAA2PRKAB1 | |
| SCHEMBL1061470 | 0.87 | TRPA1 (0.72) | TRPA1CDC25A | |
| SCHEMBL1061471 | 0.87 | TRPA1 (0.72) | TRPA1CDC25A | |
| SCHEMBL12930177 | 0.86 | TRPA1 (0.61) | TRPA1CDC25A | |
| SCHEMBL18954771 | 0.84 | KMT2A (0.72) | KMT2APRKAG1PRKAA2PRKAB1PRKAA1 | |
| SCHEMBL12930288 | 0.83 | TRPA1 (0.60) | KMT2ATRPA1CDC25A | |
| SCHEMBL28882505 | 0.81 | PRKAG1 (0.87) | KMT2ATRPA1PRKAG1PRKAA2PRKAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009379-A1 | INDOLINONE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-01-13 | — | — | US | disclosed |
| US-20110009379-A1 | INDOLINONE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-01-13 | — | — | US | disclosed |
| WO-2009123080-A1 | INDOLINONE COMPOUND | アステラス製薬株式会社 (JP) | 2009-10-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009379-A1 | INDOLINONE COMPOUND | TRPA1, TRPV1, TRPV6 | KMT2A 4114/4885TRPA1 1/4885PRKAG1 3522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.