Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1269492 | 0.94 | GAA (0.48) | ALDH1A1SMN1; SMN2LMNALRRK2GLA | |
| SCHEMBL1268653 | 0.84 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2LMNAGLAKDM4E | |
| SCHEMBL12931665 | 0.84 | LMNA (0.45) | ALDH1A1SMN1; SMN2LMNAMCOLN3LRRK2 | |
| SCHEMBL1268801 | 0.81 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2LMNAGLAGAA | |
| SCHEMBL1269704 | 0.78 | GAA (0.46) | ALDH1A1SMN1; SMN2LMNAMCOLN3LRRK2 | |
| SCHEMBL1269625 | 0.69 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2LMNAGLAGAA | |
| SCHEMBL1268542 | 0.69 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2LMNAGAAPKM | |
| SCHEMBL1269442 | 0.69 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2LMNAGLA | |
| SCHEMBL1268492 | 0.69 | GAA (0.45) | ALDH1A1SMN1; SMN2LMNAMCOLN3GLA | |
| SCHEMBL1268839 | 0.68 | MEN1 (0.42) | ALDH1A1SMN1; SMN2LMNAGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893077-B2 | Bisaryl-sulfonamides | AMGEN INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090221584-A1 | Bisaryl-sulfonamides | AMGEN INC. | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221584-A1 | Bisaryl-sulfonamides | PPARD, PPARA, PPARG | ALDH1A1 2237/4885SMN1; SMN2 4836/4885LMNA 2576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.