SCHEMBL12949554

SCHEMBL12949554

Cn1ccc(=O)c(O)c1CC(F)F

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.55
DOHH Q9BU89 2/20 0.55
KDM6A O15550 1/20 0.55
KDM4A O75164 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
KDM5C P41229 1/20 0.55
KDM2B Q8NHM5 1/20 0.55
KDM2A Q9Y2K7 1/20 0.55
TP53 P04637 1/20 0.37
CYP2D6 P10635 1/20 0.37
HTT P42858 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
COMT P21964 2/20 0.37
MMP1 P03956 1/20 0.35
MMP7 P09237 1/20 0.35
MMP9 P14780 1/20 0.35
MMP8 P22894 1/20 0.35
MMP13 P45452 1/20 0.35
APP P05067 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18117860 0.80 KDM4E (0.60) KDM4EDOHHKDM6AKDM4ACYP2C9
SCHEMBL869287 0.78 KDM4E (0.62) KDM4EDOHHKDM6AKDM4ACYP2C9
SCHEMBL6995058 0.78 KDM4E (0.62) KDM4EDOHHKDM6AKDM4ACYP2C9
SCHEMBL8615538 0.77 KDM4E (0.60) KDM4EDOHHKDM6AKDM4ACYP2C9
Hydrochloric Acid SCHEMBL6997040 0.77 KDM4E (0.60) KDM4EDOHHKDM6AKDM4ACYP2C9
Hydrochloric Acid SCHEMBL10404502 0.77 KDM4E (0.60) KDM4EDOHHKDM6AKDM4ACYP2C9
SCHEMBL2115732 0.76 KDM4E (0.55) KDM4EDOHHKDM6AKDM4ACYP2C9
SCHEMBL9353622 0.75 KDM4E (0.46) KDM4EDOHHKDM6AKDM4ACYP2C9
SCHEMBL4546216 0.75 KDM4E (0.58) KDM4EDOHHKDM6AKDM4ACYP2C9
SCHEMBL12249885 0.75 KDM4E (0.53) KDM4EDOHHKDM6AKDM4ACYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9938240-B2 Fluorinated derivatives of 3-hydroxypyridin-4-ones APOTEX INC. (CA) 2018-04-10 US disclosed
US-9938240-B2 Fluorinated derivatives of 3-hydroxypyridin-4-ones APOTEX INC. (CA) 2018-04-10 US disclosed
US-9938240-B2 Fluorinated derivatives of 3-hydroxypyridin-4-ones APOTEX INC. (CA) 2018-04-10 US disclosed
US-20170247329-A1 \"Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones\ APOTEX TECHNOLOGIES INC. (CA) 2017-08-31 US disclosed
US-20170247329-A1 \"Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones\ APOTEX TECHNOLOGIES INC. (CA) 2017-08-31 US disclosed
US-20170247329-A1 \"Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones\ APOTEX TECHNOLOGIES INC. (CA) 2017-08-31 US disclosed
US-20170088518-A1 Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones THE BANK OF NOVA SCOTIA (CA) 2017-03-30 US disclosed
US-20170088518-A1 Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones THE BANK OF NOVA SCOTIA (CA) 2017-03-30 US disclosed
US-20170088518-A1 Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones THE BANK OF NOVA SCOTIA (CA) 2017-03-30 US disclosed
US-9550733-B2 Fluorinated derivatives of 3-hydroxypyridin-4-ones APOTEX TECHNOLOGIES INC. (CA) 2017-01-24 US disclosed
US-9073865-B2 Fluorinated derivates of 3-hydroxypyridin-4-ones APOTEX TECHNOLOGIES INC. (CA) 2015-07-07 US disclosed
US-9073865-B2 Fluorinated derivates of 3-hydroxypyridin-4-ones APOTEX TECHNOLOGIES INC. (CA) 2015-07-07 US disclosed
EP-2448922-B1 FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES APOTEX TECHNOLOGIES INC (CA) 2014-08-20 EP disclosed
EP-2448922-B1 FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES APOTEX TECHNOLOGIES INC (CA) 2014-08-20 EP disclosed
CN-102712591-B Fluorinated derivatives of 3-hydroxypyridin-4-ones APOTEX TECHNOLOGIES INC 2014-06-25 CN disclosed
CN-103601673-A Fluorinated derivatives of 3-hydroxypyridin-4-ones APOTEX TECHNOLOGIES INC 2014-02-26 CN disclosed
US-20120270882-A1 FLUORINATED DERIVATES OF 3-HYDROXYPYRIDIN-4-ONES APOTEX TECHNOLOGIES INC. (CA) 2012-10-25 US disclosed
US-20120270882-A1 FLUORINATED DERIVATES OF 3-HYDROXYPYRIDIN-4-ONES APOTEX TECHNOLOGIES INC. (CA) 2012-10-25 US disclosed
US-20120270882-A1 FLUORINATED DERIVATES OF 3-HYDROXYPYRIDIN-4-ONES APOTEX TECHNOLOGIES INC. (CA) 2012-10-25 US disclosed
WO-2011000104-A1 FLUORINATED DERIVATIVES OF 3-HYDROXYPYRIDIN-4-ONES APOTEX TECHNOLOGIES INC. (CA) 2011-01-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120270882-A1 FLUORINATED DERIVATES OF 3-HYDROXYPYRIDIN-4-ONES FH, FECH, FTH1 KDM4E 3133/4885DOHH 284/4885KDM6A 3772/4885
US-20170088518-A1 Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones FH, FECH, FPGS KDM4E 2785/4885DOHH 325/4885KDM6A 3395/4885
US-20170247329-A1 \"Fluorinated Derivatives of 3-Hydroxypyridin-4-Ones\ FH, FECH, FPGS KDM4E 2376/4885DOHH 263/4885KDM6A 3191/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.