SCHEMBL1295322

SCHEMBL1295322

COC(=O)c1ccc(OCCCC2CCN(C(=O)OC(C)(C)C)CC2)cc1C

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 17/20 0.61
CHEK2 O96017 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1296310 0.90 GPR119 (0.63) GPR119CHEK2
SCHEMBL1576050 0.89 GPR119 (0.71) GPR119
SCHEMBL1839393 0.88 GPR119 (0.46) GPR119
SCHEMBL2555005 0.87 GPR119 (0.59) GPR119
SCHEMBL7376662 0.86 GPR119 (0.70) GPR119CHEK2
SCHEMBL22284267 0.86 GPR119 (0.61) GPR119
SCHEMBL20060901 0.86 GPR119 (0.61) GPR119CHEK2
SCHEMBL1295509 0.86 GPR119 (0.57) GPR119
SCHEMBL1296099 0.85 EED (0.48) GPR119
SCHEMBL1575856 0.85 GPR119 (0.64) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2321308-B9 PIPERIDINE GPCR AGONISTS PROSIDION LTD (GB) 2012-08-08 EP disclosed
EP-2321308-B9 PIPERIDINE GPCR AGONISTS PROSIDION LTD (GB) 2012-08-08 EP disclosed
EP-2321308-B1 PIPERIDINE GPCR AGONISTS PROSIDION LTD (GB) 2012-05-09 EP disclosed
EP-2321308-B1 PIPERIDINE GPCR AGONISTS PROSIDION LTD (GB) 2012-05-09 EP disclosed
US-20110269734-A1 PIPERIDINYL GPCR AGONISTS PROSIDION LIMITED (GB) 2011-11-03 US disclosed
US-20110269734-A1 PIPERIDINYL GPCR AGONISTS PROSIDION LIMITED (GB) 2011-11-03 US disclosed
US-20110269734-A1 PIPERIDINYL GPCR AGONISTS PROSIDION LIMITED (GB) 2011-11-03 US disclosed
WO-2011128394-A1 3-SUBSTITUTED 5-(PYRROLIDINE-1-CARBONYL) PYRROLIDINE AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF METABOLIC DISORDERS PROSIDION LIMITED (GB) 2011-10-20 WO disclosed
WO-2011128394-A1 3-SUBSTITUTED 5-(PYRROLIDINE-1-CARBONYL) PYRROLIDINE AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF METABOLIC DISORDERS PROSIDION LIMITED (GB) 2011-10-20 WO disclosed
WO-2011128395-A1 N- SUBSTITUTED 3-AMINO 4 - ( PYRROLIDINE - 1 - CARBONYL) PYRROLIDINE AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF METABOLIC DISORDERS PROSIDION LIMITED (GB) 2011-10-20 WO disclosed
EP-2328867-A1 HETEROCYCLIC GPCR AGONISTS Prosidion Limited (GB) 2011-06-08 EP disclosed
EP-2321305-A1 HETEROCYCLIC GPCR AGONISTS Prosidion Limited (GB) 2011-05-18 EP disclosed
EP-2321297-A1 PIPERIDINYL GPCR AGONISTS Prosidion Limited (GB) 2011-05-18 EP disclosed
WO-2010004344-A1 PIPERIDINE GPCR AGONISTS PROSIDION LIMITED (GB) 2010-01-14 WO disclosed
WO-2010004343-A1 PIPERIDINYL GPCR AGONISTS PROSIDION LIMITED (GB) 2010-01-14 WO disclosed
WO-2010004343-A1 PIPERIDINYL GPCR AGONISTS PROSIDION LIMITED (GB) 2010-01-14 WO disclosed
WO-2010004348-A1 HETEROCYCLIC GPCR AGONISTS PROSIDION LIMITED (GB) 2010-01-14 WO disclosed
WO-2010004348-A1 HETEROCYCLIC GPCR AGONISTS PROSIDION LIMITED (GB) 2010-01-14 WO disclosed
WO-2010004347-A1 HETEROCYCLIC GPCR AGONISTS PROSIDION LIMITED (GB) 2010-01-14 WO disclosed
WO-2010004347-A1 HETEROCYCLIC GPCR AGONISTS PROSIDION LIMITED (GB) 2010-01-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110269734-A1 PIPERIDINYL GPCR AGONISTS GPR119, GPR27, GLP1R GPR119 1/4885CHEK2 3863/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.