Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288697 | 0.87 | NAMPT (0.45) | ALDH1A1POLBNAMPTBRAFHDAC3 | |
| SCHEMBL14613333 | 0.86 | EPHB4 (0.45) | BRAFABL1LMNA | |
| SCHEMBL14043329 | 0.85 | KISS1R (0.38) | NAMPTHDAC1 | |
| SCHEMBL14418847 | 0.85 | CSNK2A1 (0.36) | HDAC1 | |
| SCHEMBL14418774 | 0.85 | FYN (0.41) | ALDH1A1LMNAKDM4EKMT2ATDP1 | |
| SCHEMBL13288852 | 0.82 | ALDH1A1 (0.41) | ALDH1A1POLBNAMPTBRAFHDAC3 | |
| SCHEMBL13120262 | 0.82 | CDK2 (0.54) | ALDH1A1POLBNAMPTTP53BP1ABL1 | |
| SCHEMBL14581427 | 0.81 | POLB (0.47) | ALDH1A1POLBLMNAKDM4EKMT2A | |
| SCHEMBL14613372 | 0.80 | HDAC1 (0.41) | ALDH1A1HDAC3HDAC1SMN1; SMN2 | |
| SCHEMBL14613373 | 0.79 | EPHX2 (0.44) | NAMPTHDAC3HDAC1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |