Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 4/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2896462 | 0.85 | ALDH1A1 (0.48) | ALDH1A1POLBLMNACYP4F2CYP4A11 | |
| SCHEMBL8242935 | 0.80 | ALDH1A1 (0.43) | ALDH1A1POLBLMNACYP4F2CYP4A11 | |
| SCHEMBL3717759 | 0.75 | CYP4F2 (0.44) | ALDH1A1POLBLMNACYP4F2CYP4A11 | |
| SCHEMBL23933195 | 0.74 | LMNA (0.38) | ALDH1A1POLBLMNACYP4F2CYP4A11 | |
| SCHEMBL23933193 | 0.74 | LMNA (0.38) | ALDH1A1POLBLMNACYP4F2CYP4A11 | |
| SCHEMBL1008524 | 0.74 | ALDH1A1 (0.48) | ALDH1A1POLBLMNACYP4F2CYP4A11 | |
| SCHEMBL12085240 | 0.74 | ALDH1A1 (0.48) | ALDH1A1POLBLMNACYP4F2CYP4A11 | |
| SCHEMBL25795329 | 0.74 | RXRA (0.46) | ALDH1A1POLBLMNACYP4F2CYP4A11 | |
| SCHEMBL31641559 | 0.73 | ALDH1A1 (0.47) | ALDH1A1POLBLMNACYP4F2CYP4A11 | |
| SCHEMBL14903852 | 0.72 | CYP4F2 (0.47) | ALDH1A1POLBLMNACYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966220-B1 | MGLUR1 ANATGONISTS AS THERAPEUTIC AGENTS | SCHERING CORP (US) | 2011-01-26 | — | — | EP | disclosed |