Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 7/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 7/20 | 0.56 |
| ▸ | RELA | Q04206 | 7/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Xanthohumol B SCHEMBL29934961 | 1.00 | NFKB1 (0.56) | NFKB1NFKB2RELADPP4PDPK1 | |
| SCHEMBL30834905 | 0.85 | NFKB1 (0.53) | NFKB1NFKB2RELADPP4PDPK1 | |
| SCHEMBL14249292 | 0.83 | NFKB1 (0.78) | NFKB1NFKB2RELADPP4PDPK1 | |
| SCHEMBL14249291 | 0.83 | NFKB1 (0.78) | NFKB1NFKB2RELADPP4PDPK1 | |
| SCHEMBL15704340 | 0.81 | NFKB1 (0.54) | NFKB1NFKB2RELADPP4PDPK1 | |
| SCHEMBL5997891 | 0.79 | MAOB (0.52) | NFKB1NFKB2RELATDP1MAPT | |
| SCHEMBL14523845 | 0.79 | MAOB (0.52) | NFKB1NFKB2RELATDP1MAPT | |
| SCHEMBL19221626 | 0.78 | NFKB1 (0.55) | NFKB1NFKB2RELADPP4PDPK1 | |
| SCHEMBL25256060 | 0.77 | MAPT (0.53) | NFKB1NFKB2RELAMAPTNPSR1 | |
| SCHEMBL31398714 | 0.76 | NFKB1 (0.83) | NFKB1NFKB2RELADPP4TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104586945-A | Hop total flavonoid extract as well as preparation method and application thereof in preparing medicines for preventing and treating liver injury and cancers | UNIV SHENYANG PHARMACEUTICAL | 2015-05-06 | — | — | CN | claimed |
| CN-101444139-A | Compositions exhibiting inhibition of cyclooxygenase-2 | METAPROTEOMICS LLC (US) | 2009-05-27 | — | — | CN | claimed |
| CN-101433561-A | Remedies | TAKARA BIO INC (JP) | 2009-05-20 | — | — | CN | claimed |
| CN-101132698-A | Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2 | METAPROTEOMICS LLC (US) | 2008-02-27 | — | — | CN | claimed |
| CN-1436074-A | Remedies | TAKARA BIO INC (JP) | 2003-08-13 | — | — | CN | claimed |
| CN-1422159-A | Therapeutic agents | TAKARA SHUZO CO (JP) | 2003-06-04 | — | — | CN | claimed |
| CN-104586945-B | Hops extractive of general flavone, preparation method and its as prepare prevention and treatment hepatic injury, the application of cancer drug | 沈阳药科大学 | 2018-06-19 | — | — | CN | disclosed |
| CN-108164382-A | A kind of method of extraction chromocor compound comprehensive from hops | 玉门拓璞科技开发有限责任公司 | 2018-06-15 | — | — | CN | disclosed |
| CN-104257762-B | A kind of pharmaceutical composition and prevention thereof and the osteoporotic purposes for the treatment of | 长春工业大学 | 2016-07-06 | — | — | CN | disclosed |
| US-20150283098-A1 | PRENYLATED CHALCONE FORMULATION FOR THE TREATMENT OF BEES | BIOACTIVE-TECH SP Z.O.O. (PL) | 2015-10-08 | — | — | US | disclosed |
| US-20150283098-A1 | PRENYLATED CHALCONE FORMULATION FOR THE TREATMENT OF BEES | BIOACTIVE-TECH SP Z.O.O. (PL) | 2015-10-08 | — | — | US | disclosed |
| CN-104586945-A | Hop total flavonoid extract as well as preparation method and application thereof in preparing medicines for preventing and treating liver injury and cancers | UNIV SHENYANG PHARMACEUTICAL | 2015-05-06 | — | — | CN | disclosed |
| CN-104257762-A | Drug combination and purpose for preventing and curing osteoporosis | ZHAO QUANCHENG | 2015-01-07 | — | — | CN | disclosed |
| CN-101505742-A | Beta acid based protein kinase modulation cancer treatment | METAPROTEOMICS LLC (US) | 2009-08-12 | — | — | CN | disclosed |
| CN-101444139-A | Compositions exhibiting inhibition of cyclooxygenase-2 | METAPROTEOMICS LLC (US) | 2009-05-27 | — | — | CN | disclosed |
| CN-101433561-A | Remedies | TAKARA BIO INC (JP) | 2009-05-20 | — | — | CN | disclosed |
| CN-100457124-C | Therapeutic agents | TAKARA BIO INC (JP) | 2009-02-04 | — | — | CN | disclosed |
| CN-101132698-A | Curcuminoid compositions exhibiting synergistic inhibition of the expression and/or activity of cyclooxygenase-2 | METAPROTEOMICS LLC (US) | 2008-02-27 | — | — | CN | disclosed |
| CN-1436074-A | Remedies | TAKARA BIO INC (JP) | 2003-08-13 | — | — | CN | disclosed |
| CN-1422159-A | Therapeutic agents | TAKARA SHUZO CO (JP) | 2003-06-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150283098-A1 | PRENYLATED CHALCONE FORMULATION FOR THE TREATMENT OF BEES | API5, CYP51A1, CYP46A1 | NFKB1 480/4885NFKB2 858/4885RELA 979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.