Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689671 | 0.85 | SMN1; SMN2 (0.56) | LMNARAB9APOLBTP53SMN1; SMN2 | |
| SCHEMBL12933423 | 0.84 | POLB (0.53) | LMNARAB9APOLBTP53SMN1; SMN2 | |
| SCHEMBL19049515 | 0.83 | LMNA (0.61) | LMNARAB9APOLBTP53SMN1; SMN2 | |
| SCHEMBL28069319 | 0.81 | CYP1A2 (0.64) | LMNARAB9APOLBSMN1; SMN2CYP1A2 | |
| SCHEMBL179074 | 0.80 | SMN1; SMN2 (0.63) | LMNARAB9APOLBTP53SMN1; SMN2 | |
| SCHEMBL31123005 | 0.80 | SMN1; SMN2 (0.63) | LMNARAB9APOLBTP53SMN1; SMN2 | |
| SCHEMBL720666 | 0.79 | POLB (0.66) | LMNARAB9APOLBSMN1; SMN2CYP1A2 | |
| SCHEMBL24863183 | 0.79 | TDP1 (0.66) | LMNARAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL874574 | 0.77 | CYP1A2 (0.59) | LMNARAB9APOLBSMN1; SMN2CYP1A2 | |
| SCHEMBL30089425 | 0.77 | CYP1A2 (0.59) | LMNARAB9APOLBSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868204-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| US-7838520-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2010-11-23 | — | — | US | disclosed |
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |