Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | MGLL | Q99685 | 2/20 | 0.64 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | GABRD | O14764 | 1/20 | 0.57 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.57 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.57 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.57 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.57 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.57 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.57 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | UBE2M | P61081 | 1/20 | 0.56 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735405 | 0.91 | HTT (0.63) | HPGDMGLLHSD11B1EPHX2L3MBTL1 | |
| SCHEMBL14220733 | 0.91 | HTT (0.63) | HPGDMGLLHSD11B1EPHX2L3MBTL1 | |
| SCHEMBL8054515 | 0.88 | HPGD (0.69) | HPGDMGLLHSD11B1EPHX2L3MBTL1 | |
| SCHEMBL7130857 | 0.87 | HPGD (0.83) | HPGDMGLLHSD11B1L3MBTL1HTT | |
| SCHEMBL14238822 | 0.87 | HPGD (0.83) | HPGDMGLLHSD11B1L3MBTL1HTT | |
| SCHEMBL23417312 | 0.86 | HPGD (0.68) | HPGDMGLLHSD11B1EPHX2L3MBTL1 | |
| SCHEMBL9633335 | 0.86 | HPGD (0.68) | HPGDMGLLHSD11B1EPHX2L3MBTL1 | |
| SCHEMBL14255587 | 0.85 | MGLL (0.68) | HPGDMGLLHSD11B1EPHX2L3MBTL1 | |
| SCHEMBL2667154 | 0.84 | HPGD (0.64) | HPGDMGLLHSD11B1EPHX2L3MBTL1 | |
| SCHEMBL12976 | 0.84 | HPGD (0.64) | HPGDMGLLHSD11B1EPHX2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |
| EP-1905762-A1 | PYRAZOLONE DERIVATIVE | Genecare Research Institute Co., Ltd (JP) | 2008-04-02 | — | — | EP | disclosed |